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I am confused about my CTS9733 result from Big Y

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  • I am confused about my CTS9733 result from Big Y

    At FTDNA, in the Known SNPs tab of Big Y I can see for myself (a R-P312 person)
    SNP Name CTS9733
    Derived? No(-)
    On Y-Tree? No
    Reference C
    Genotype C
    Confidence High

    And for another project member (who is R-U106)
    SNP Name CTS9733
    Derived? Yes(+)
    On Y-Tree? No
    Reference C
    Genotype T
    Confidence High

    You would think that if somebody has C, then he does not have CTS9733.

    But then I am looking at
    http://ybrowse.org/gb2/gbrowse_detai...hrY%3Adatabase
    and
    http://www.yseq.net/product_info.php?products_id=2226
    Both pages аssumе that the mutation is from T to C.

    None of us has CTS9733 listed on the Y-DNA Haplotree page at FTDNA or on the SNP certificate.

    Why did I even look?

    I was sent a typical reading by YFull from someone who has CTS9733:
    ChrY position: 19045124 (+strand)
    Reads: 67
    Position data: 2A 65C
    Weight for A: 0.026622296173
    Weight for C: 0.973377703827
    Probability of error: 0.0376496123094 (0<->1)
    Sample allele: C
    Reference (hg19) allele: C
    Known SNPs at this position: CTS9733 • S3856 (T->C)

    Should I phone FTDNA (send in a form with a query?) or learn more first ? If the latter, what did I miss?

    Thank you in advance for any insight - Mr. W.

  • #2
    Originally posted by dna View Post
    At FTDNA, in the Known SNPs tab of Big Y I can see for myself (a R-P312 person)
    SNP Name CTS9733
    Derived? No(-)
    On Y-Tree? No
    Reference C
    Genotype C
    Confidence High

    And for another project member (who is R-U106)
    SNP Name CTS9733
    Derived? Yes(+)
    On Y-Tree? No
    Reference C
    Genotype T
    Confidence High

    You would think that if somebody has C, then he does not have CTS9733.

    But then I am looking at
    http://ybrowse.org/gb2/gbrowse_detai...hrY%3Adatabase
    and
    http://www.yseq.net/product_info.php?products_id=2226
    Both pages аssumе that the mutation is from T to C.

    None of us has CTS9733 listed on the Y-DNA Haplotree page at FTDNA or on the SNP certificate.

    Why did I even look?

    I was sent a typical reading by YFull from someone who has CTS9733:
    ChrY position: 19045124 (+strand)
    Reads: 67
    Position data: 2A 65C
    Weight for A: 0.026622296173
    Weight for C: 0.973377703827
    Probability of error: 0.0376496123094 (0<->1)
    Sample allele: C
    Reference (hg19) allele: C
    Known SNPs at this position: CTS9733 • S3856 (T->C)

    Should I phone FTDNA (send in a form with a query?) or learn more first ? If the latter, what did I miss?

    Thank you in advance for any insight - Mr. W.
    In some cases the reference allele is the derived state rather than the ancestral state. That may be the case for CTS9733. It would be better if BigY showed the ancestral/derived states rather than reference/your result to avoid this confusion.

    Comment


    • #3
      Originally posted by David Guetta View Post
      In some cases the reference allele is the derived state rather than the ancestral state. That may be the case for CTS9733. It would be better if BigY showed the ancestral/derived states rather than reference/your result to avoid this confusion.
      Thank you! At least I can see that I was jumping to conclusions due to not understanding fundamentals.

      Mr. W.

      Comment


      • #4
        Originally posted by dna View Post
        At FTDNA, in the Known SNPs tab of Big Y I can see for myself (a R-P312 person)
        SNP Name CTS9733
        Derived? No(-)
        On Y-Tree? No
        Reference C
        Genotype C
        Confidence High

        And for another project member (who is R-U106)
        SNP Name CTS9733
        Derived? Yes(+)
        On Y-Tree? No
        Reference C
        Genotype T
        Confidence High

        You would think that if somebody has C, then he does not have CTS9733.

        But then I am looking at
        http://ybrowse.org/gb2/gbrowse_detai...hrY%3Adatabase
        and
        http://www.yseq.net/product_info.php?products_id=2226
        Both pages аssumе that the mutation is from T to C.

        None of us has CTS9733 listed on the Y-DNA Haplotree page at FTDNA or on the SNP certificate.

        Why did I even look?

        I was sent a typical reading by YFull from someone who has CTS9733:
        ChrY position: 19045124 (+strand)
        Reads: 67
        Position data: 2A 65C
        Weight for A: 0.026622296173
        Weight for C: 0.973377703827
        Probability of error: 0.0376496123094 (0<->1)
        Sample allele: C
        Reference (hg19) allele: C
        Known SNPs at this position: CTS9733 • S3856 (T->C)

        Should I phone FTDNA (send in a form with a query?) or learn more first ? If the latter, what did I miss?

        Thank you in advance for any insight - Mr. W.
        CTS9733 is under L20 at yfull. I looked at the U106 Big Y results and it is not among any of the results.

        Comment


        • #5
          S3856*

          My postion on the BigY tree has recently changed from L20/S144 to CTS9733 S3856 YSC0000193

          There are 8 kits in this group mine is among 3 that are S3856*
          The other 5 are downstream from us?

          Mutations in Block
          17005069-T-A YSC0000193
          19045124-T-C CTS9733 S3856

          Where can I find out more about these mutations?
          Regards
          Colin

          Comment


          • #6
            I assume you are already on YFull's tree?

            Comment


            • #7
              in addition to YFull you can also send your results to the Big Y tree. Your group is shown below:
              http://ytree.net/DisplayTree.php?blockID=1300

              Oh sorry disrard my post above I now see you posted YOUR position changed on the Big Tree. Sorry.
              Last edited by thetick; 20 January 2016, 03:28 PM.

              Comment

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