H-T195C! - help, no info on this haplogroup...

[Cosa917]

Hello all,

My maternal line is from northern morocco. I got assigned to haplogroup H-T195C! but I couldn't find any info on its origin, distribution etc... I got an italian match with the same haplogroup (FMS 3), and 2 other italian matches for HVR1 and HVR2 each.

However, I submitted my sample in yfull and got assigned to sub-branch H-c2 https://www.yfull.com/mtree/H-c2/ grouped together with an Armenian and another Italian sample. Due to the high number of italians that seem to match, is it safe to think that my subranch comes from there?

Here are my extra mutations if it's of any relevance: 315.1C
522.1A
522.2C
A2060G
G4655A
A8008G
G9663A
A16051G
C16248T
C16519T

Were are all grouped under mutation A2060G.

[khazaria]

There are occasionally errors in the haplogroup assignments in YFull's MTree.

When it comes to the Italy sample JN415472, Ian Logan places it within H66 at http://www.ianlogan.co.uk/sequences_..._sequences.htm partly on the basis of it containing the mutation G7337A that defines H66. "List of complete mtDNA sequences included in Figure 1" within the 2012 study "Rare Primary Mitochondrial DNA Mutations and Probable Synergistic Variants in Leber’s Hereditary Optic Neuropathy" similarly lists JN415472 as H66.

Another sample from Italy, MN687208, is likewise in H66 according to both Ian and MTree.

But, as you saw, MTree is using another mutation, A2060G, to define what they call H-c2, as a child of H-c, not within the H66 tree, and they include JN415472 in H-c2. Perhaps this needs more research or refinement?

I don't yet know what haplogroup Ian would place samples KY410091 and KY408241 into. YFull's MTree calls them members of H-c3. GenBank at https://www.ncbi.nlm.nih.gov/nuccore/KY408241.1 and https://www.ncbi.nlm.nih.gov/nuccore/KY410091.1 say those are from Sardinia and members of haplogroup H2.

[Cosa917]

Thank you for your reply, that's interesting. I wonder why the italian sample is grouped with us under A2060G but still has the defining mutation for H66. Could it be that A2060G is simple a defining mutation for a broader subclade that includes H66?

I also spoke with Ian Logan and here is what I got told concerning my case:
The mutation G9663A is uncommon. Found in only 15 sequences on GenBank (out of 50,000+ sequences). There are single sequences in Haplogroups L2b1a, T2b X2e2b. And, 12 sequences in Haplogroup M28a5a. Also, the mutation A8008G is very uncommon. This gives you a very unique motif 'H-T195-A8008G-G9663A' which is going to occur only in your closest relations.