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HV0 Extra Mutations

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  • #1

    HV0 Extra Mutations

    Hi all - I have recently had my mtDNA results from FTDNA (still waiting on Family Finder at this point). I was classified as "HV0-T195C!". It has taken me a while to figure out how it all works and I think I have most of it worked out now. So, all the mutations I have in my mitochondria are an accumulation of mutations from Mitochondrial Eve (Haplogroup L) up to now. I am using RSRS for my analysis. So far, so good.

    Except ... I have two "missing" mutations (C16189T, T16298C) and 10 "extra" mutations.

    My question is: how can I be classified as HV0 with both missing and extra mutations? It seems to me that it's a subclade of HV0 that maybe just hasn't been defined yet. Would this be a reasonable assumption to make? (The existing HV0 subclades do not match with my extra mutations.)

    A hypothetical question: one of my missing mutations (T16362C) can actually be found in an ancestral haplogroup R0a'b. There are two other mutations one of which I have (C64T, otherwise classified as extra) and one which I don't have (T2442C). So, is it hypothetically possible that there's a haplogroup between R0 and R0a'b from which I am descended and which also hasn't (yet) been defined?

    I'm hoping someone can answer these questions because I really like to know how these things hang together.

    Thanks!

    Cheryl
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  • #2
    I think that is an advanced question.

    And I hope someone knows how to explain it in simple terms.


    Mr. W.

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    • #3
      You can run your results through James Lick's utility to see what he comes up with for the path. Use your values from the rCRS tab, not the RSRS.

      http://dna.jameslick.com/mthap-new

      If you have some close matches, you presumably would share one or more of your "extras" and that could indeed become the motif for a new subclade. You would all need to upload your sequences to GenBank to get an official label. Ian Logan has instructions on how to upload to GenBank at http://www.ianlogan.co.uk/submission.htm.

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      • #4
        Originally posted by Ann Turner View Post
        You can run your results through James Lick's utility to see what he comes up with for the path. Use your values from the rCRS tab, not the RSRS.

        http://dna.jameslick.com/mthap-new
        Thanks Ann for the suggestion. I'm not sure I'm any the wiser at this stage though! I might try sending an email to James to see if he can help.

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