FGS results

[Deirwha]

A couple of questions?

Why doesn't Mitosearch upload FGS?

Why couldn't Mitosearch distinguish "private" mutations from not and call an FGS 1:1 relationship but for the private mutations a "match"?


Maybe I am making an incorrect assumption here based on a misinterpretation of my own experience. So feel free to correct my assumptions here.

[darroll]

What's FGS?

[rucksack]

A couple of questions?

Why doesn't Mitosearch upload FGS?

Why couldn't Mitosearch distinguish "private" mutations from not and call an FGS 1:1 relationship but for the private mutations a "match"?


Maybe I am making an incorrect assumption here based on a misinterpretation of my own experience. So feel free to correct my assumptions here.

First, darroll, FGS means Full Genomic Sequence [of the mtDNA]. It is a test that gives you ALL you would ever need or want to know about the DNA on the mitochondrial segment of your DNA. That mtDNA is ONLY passed down from mother to mother to mother to mother, and it is also passed down to any of her children. Female children will continue to pass it down, male children HAVE the same mtDNA as their mothers, but do NOT pass it down to their children. Only the mother of your children would pass this type of DNA down to her/your children, if you are a male.

The FGS contains information that "could" be information that you might want to keep from others, particularly given the fact that it is more or less "public".

The FGS sequences the Coding Region, and within the Coding region, there are certain mitochondrial disease "possibilities". I say "possibilities", because even with a certain mutation that "could" indicate that or another disease, it does not necessarily mean you HAVE the disease or could even pass it on to another generation. That second part is a FOR SURE if you are male, since males do not pass on anything in the mitochondrion.

There are still resources available to you.

The mtDB hosted in Uppsala, Sweden, the GenBank resources and a few others, including Ian Logan's mtDNA Haplotree and others.

If you are still curious or want more info, just ask. I'll post "how to" info. I won't elaborate unless you want to know more, BUT there is more.

Take care,

[rucksack]

A couple of questions?

Why doesn't Mitosearch upload FGS?

Why couldn't Mitosearch distinguish "private" mutations from not and call an FGS 1:1 relationship but for the private mutations a "match"?


Maybe I am making an incorrect assumption here based on a misinterpretation of my own experience. So feel free to correct my assumptions here.

First, darroll, FGS means Full Genomic Sequence [of the mtDNA]. It is a test that gives you ALL you would ever need or want to know about the DNA on the mitochondrial segment of your DNA. That mtDNA is ONLY passed down from mother to mother to mother to mother, and it is also passed down to any of her children. Female children will continue to pass it down, male children HAVE the same mtDNA as their mothers, but do NOT pass it down to their children. Only the mother of your children would pass this type of DNA down to her/your children, if you are a male.

The FGS contains information that "could" be information that you might want to keep from others, particularly given the fact that it is more or less "public".

The FGS sequences the Coding Region, and within the Coding region, there are certain mitochondrial disease "possibilities". I say "possibilities", because even with a certain mutation that "could" indicate that or another disease, it does not necessarily mean you HAVE the disease or could even pass it on to another generation. That second part is a FOR SURE if you are male, since males do not pass on anything in the mitochondrion.

There are still resources available to you.

The mtDB hosted in Uppsala, Sweden, the GenBank resources and a few others, including Ian Logan's mtDNA Haplotree and others.

If you are still curious or want more info, just ask. I'll post "how to" info. I won't elaborate unless you want to know more, BUT there is more.

Take care,

[rainbow]

What's FGS?

LOL! That was my first laugh of the day. Thanks for that. I had a stressful day evening and you lifted my mood. On a side note, I never orered my FGS. And if ever do, I don't want it public. It is something very important that should be protected like a Social Security number.

[darroll]

Thanks very much for the information.
I do not have my FGS posted anywhere and I won't.

[darroll]

I do have my HVR1 and HVR2 posted on Mitosearch though.
HVR2 told us where we came from thru NG/FTDNA.

[Deirwha]

Thanks

The FGS contains information that "could" be information that you might want to keep from others, particularly given the fact that it is more or less "public".


There are still resources available to you.

The mtDB hosted in Uppsala, Sweden, the GenBank resources and a few others, including Ian Logan's mtDNA Haplotree and others.

If you are still curious or want more info, just ask. I'll post "how to" info. I won't elaborate unless you want to know more, BUT there is more.

Take care,

Thanks. I believe the arrangements mentioned in the last two paragraphs will be made when the T FGS project is complete. I have not been as worried about the privacy issue for the reason that if I choose to upload it then I am not worried about my privacy and if my extremely few matches are worried they don't have to upload. So whose privacy have we protected?
I can see and respect reasons why not everyone would want to upload. The most likely locus, however, for that kind of information, at least in my case (and I am sure someone will let us know if this is not true generally) would be contained on my "private" mutations. I was hoping for a mechanism that would segregate out those private mutation and deal with commonalities for search purposes. Anybody thereby found could share or not as they saw fit. Of course, my personal attitude is I don't mind being asked. I can always say no and would try to be nice about it. But I know that even the question can cause discomfort. I was not looking for a uniform system to be required of everyone but a capability so, selfishly, everything of mine could be found at one place, for me FT DNA and its linked up mitosearch. This is not a knock on anyone else but a statement of faith in FT DNA. In the end, as I mentioned in the beginning it appears this will soon be moot. I had not realized that the other day when I posted the questions. Thanks all for your comments.

[efgen]

I was hoping for a mechanism that would segregate out those private mutation and deal with commonalities for search purposes.

There's nothing in the DNA that tags a mutation as private. The only way to determine that a mutation is private is by finding nobody else who has that mutation Of course, the number of people who have done FGS testing is minuscule compared to the population, so what might appear to be private today may turn out to not be private in the future.

The only *certain* non-private mutations are those that define the branches of the mtDNA tree. But if all we're comparing are branch-defining mutations, then all we get is a list of matches who belong to the same subclade. There are additional mutations that are neither branch-defining nor private, and without those, we have no ability to find closer matches. This would be like knowing your Y-DNA subclade, but not having STR marker results to compare with other people to find more recent genealogical matches.

Elise

[darroll]

Good comments.

[Deirwha]

Good comments

There's nothing in the DNA that tags a mutation as private. The only way to determine that a mutation is private is by finding nobody else who has that mutation Of course, the number of people who have done FGS testing is minuscule compared to the population, so what might appear to be private today may turn out to not be private in the future.

The only *certain* non-private mutations are those that define the branches of the mtDNA tree. But if all we're comparing are branch-defining mutations, then all we get is a list of matches who belong to the same subclade. There are additional mutations that are neither branch-defining nor private, and without those, we have no ability to find closer matches. This would be like knowing your Y-DNA subclade, but not having STR marker results to compare with other people to find more recent genealogical matches.

Elise

All points well taken and as noted earlier, it will soon be moot for me as I will eventually be posted in GenBank.

[rainbow]

Maybe someday I'll order the FGS even though it won't help me find out more about the mysterious AmerIndian autosomal dna from my father. I've seen the term FGS on this forum a gazillion times and it makes me feel it is a must-have. When I only knew that I was an mtdna H with HVR1 I would read posts and signatures about the subclades of H and

[rainbow]

Post continued

I wondered what my subclade was. Instead of ordering the FGS I ordered the h subclade-refinement test. My result was-is- H1. I had thought I would know my HVR2 mutations along with subclade just like nearly everyone who has it listed in their signature. But it turns out I was mistaken and it doesn't include the HVR2. If I want to know my HVR2 I would have to order the FGS which would have additional info I wouldn't know what to do with. The h subclade test is no longer offered. Anyone who wants to know their subclade will need to order their FGS. That it as far as I know.

[Deirwha]

Fgs

Maybe someday I'll order the FGS even though it won't help me find out more about the mysterious AmerIndian autosomal dna from my father. I've seen the term FGS on this forum a gazillion times and it makes me feel it is a must-have. When I only knew that I was an mtdna H with HVR1 I would read posts and signatures about the subclades of H and

It both helps and hurts that there are so few within my little group relative to yours. I don't really know where to take all this now. I have learned a lot, it seems to me, but there are limits and a major one is how many people are in the comparison pool. Another is the standards by which we compare to each other and the extent of our real knowledge as to what it is really all about, Alfie. Sometimes it feels like, uh huh, ok and ... then what? I will not regret having done my FGS, but sometimes I wish I had a few million dollars to offer to a random sample that I could somehow target to expand the base of knowledge beyond the self selection of those who can afford it, know about it, are curious, and not otherwise afraid of what they may find.

[JuanCarlos]

I ordered the FGS test from FTDNA, when they were offering at a reduced price for those who qualified, and I did. I still have not received my results, they are expected in June. I already know my subclade which is H6a. What else can I expect to learn from the FGS, ancestry related?