Basic HVR1+2 Question

[douggill]

Trying to understand the depth of HVR results as they relate to determining a MRCA. This seems much more complicated than the "Y" Chromosome.

My HVR results give me a U4 Haplogroup. I show HVR 1+2 links with four other individuals who are -1 separation on combined HVR results.

My questions are:
1. What can one deduce from a -1 separation in terms of relationships?
Would we expect to see a "genealogical linkage" at this level or is this level of separation beyond a genealogical timeframe?

2. Does anyone know of a haplotype U4 mailing list group?

Thanks for any clarification you can provide

Doug Gill

[Julilla]

Doug, I can't answer your question about what a -1 means, but I am a U4 and I'd be interested in participating in a U4 group if you want to start one!

[JSW]

mtDNA almost matches

Since mtDNA mutates so slowly any difference can and probably does
mean any common ancestor is several thousands of years in the past.
Say 5,000 or 10,000. But since it is all random it could be that just you
are the one with that mutation. You have to look at the odds one
way or the other. The odds are on the order of 1,000,000 to one
against you being the one.

[Clara]

U5 varieties

I'm a "U5a1a" whatever that means!

I notice that my mutations go this way...
16192T, 16256T, 16270T, 16291T, & 16399G [all HVR1 differences]

I also have 73G, 263G, & 315.1C [all HVR 2 differences].

What this means, I am not certain as yet.

Clara

[jr75]

U5a1a

I am also a "U5a1a" member

From my readings - I would say we are Nordic/Vikings in origin

Jane

[Padgett]

I'm also U4 and there seems to be quite a few of us springing up. I'm thinking of having a cousin of mine tested (she's almost 70 years old and is the daughter of my great grandmother's sister. This would at least let me know if the mutation occurred since my great grandmother was born.

[peeceful]

Hvr2 results

Hello everyone,

Can anyone explain this to me? I have brain freeze
Thank you.

73G
150T
195C
198T
263G
315.1C

•Jorde,95; 34; Tsonga(1) MTDNA Concordance

[vraatyah]

Can anyone explain this to me? I have brain freeze
Thank you.

73G
150T
195C
198T
263G
315.1C

more likely to be in L3e. What is the hvs1?

[peeceful]

more likely to be in L3e. What is the hvs1?

Thank You for responding.
My hvr1 is

16068c
16223t
16320t
16519c

[vraatyah]

That's definitely a L3e although this variant has nothing indicative of subclades. Trovoada recently published several sequences that match both your hvs1 and 2 except for 16068. Another example occured in SWGDAM, it lacks 16068 transition too.

[peeceful]

That's definitely a L3e although this variant has nothing indicative of subclades. Trovoada recently published several sequences that match both your hvs1 and 2 except for 16068. Another example occured in SWGDAM, it lacks 16068 transition too.

Thank you again. Can you direct me to the recently published information on L3e? I find studies placing L3e in Ethiopia and among Yemens is this correct?
I also see L3e in Afro- Brazillian and Portuguese. I think I understand the connection.

Diane

[vraatyah]

Thank you again. Can you direct me to the recently published information on L3e? I find studies placing L3e in Ethiopia and among Yemens is this correct?
I also see L3e in Afro- Brazillian and Portuguese. I think I understand the connection.

Diane

The paper you found is Kivisild et al. 2004 article which describes haplogroup motifs by the example of Ethiopian ones. It doesn't mean that all Ls found in Ethiopians are East African in origin, of course. However, the ultimate origin of L3 seems to be prehistoric East African.

As to published 16223-16320 sequences, they are mostly West/Central African and African-American.

[peeceful]

That's definitely a L3e although this variant has nothing indicative of subclades. Trovoada recently published several sequences that match both your hvs1 and 2 except for 16068. Another example occured in SWGDAM, it lacks 16068 transition too.

Can you please help me with this?
When comparing results with someone,
what does it mean when the HVR 1 is -3 mutations and HVR2 is -1 mutation.
Would there be a common ancestor?

Thanks

[vineviz]

Can you please help me with this?
When comparing results with someone,
what does it mean when the HVR 1 is -3 mutations and HVR2 is -1 mutation.
Would there be a common ancestor?

This question has gone unanswered for a long time, but the answer is almost certainly "no". Four differences is a HUGE amount of difference in mtDNA, genealogically speaking. The probability of a recent common ancestor (i.e. within a couple thousand years) is very low.