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Basic HVR1+2 Question

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  • Basic HVR1+2 Question

    Trying to understand the depth of HVR results as they relate to determining a MRCA. This seems much more complicated than the "Y" Chromosome.

    My HVR results give me a U4 Haplogroup. I show HVR 1+2 links with four other individuals who are -1 separation on combined HVR results.

    My questions are:
    1. What can one deduce from a -1 separation in terms of relationships?
    Would we expect to see a "genealogical linkage" at this level or is this level of separation beyond a genealogical timeframe?

    2. Does anyone know of a haplotype U4 mailing list group?

    Thanks for any clarification you can provide

    Doug Gill

  • #2
    Doug, I can't answer your question about what a -1 means, but I am a U4 and I'd be interested in participating in a U4 group if you want to start one!

    Comment


    • #3
      mtDNA almost matches

      Since mtDNA mutates so slowly any difference can and probably does
      mean any common ancestor is several thousands of years in the past.
      Say 5,000 or 10,000. But since it is all random it could be that just you
      are the one with that mutation. You have to look at the odds one
      way or the other. The odds are on the order of 1,000,000 to one
      against you being the one.

      Comment


      • #4
        U5 varieties

        I'm a "U5a1a" whatever that means!

        I notice that my mutations go this way...
        16192T, 16256T, 16270T, 16291T, & 16399G [all HVR1 differences]

        I also have 73G, 263G, & 315.1C [all HVR 2 differences].

        What this means, I am not certain as yet.

        Clara

        Comment


        • #5
          U5a1a

          I am also a "U5a1a" member

          From my readings - I would say we are Nordic/Vikings in origin

          Jane

          Comment


          • #6
            I'm also U4 and there seems to be quite a few of us springing up. I'm thinking of having a cousin of mine tested (she's almost 70 years old and is the daughter of my great grandmother's sister. This would at least let me know if the mutation occurred since my great grandmother was born.

            Comment


            • #7
              Hvr2 results

              Hello everyone,

              Can anyone explain this to me? I have brain freeze
              Thank you.

              73G
              150T
              195C
              198T
              263G
              315.1C

              •Jorde,95; 34; Tsonga(1) MTDNA Concordance

              Comment


              • #8
                Originally posted by peeceful
                Can anyone explain this to me? I have brain freeze
                Thank you.

                73G
                150T
                195C
                198T
                263G
                315.1C
                more likely to be in L3e. What is the hvs1?

                Comment


                • #9
                  Originally posted by vraatyah
                  more likely to be in L3e. What is the hvs1?
                  Thank You for responding.
                  My hvr1 is

                  16068c
                  16223t
                  16320t
                  16519c

                  Comment


                  • #10
                    That's definitely a L3e although this variant has nothing indicative of subclades. Trovoada recently published several sequences that match both your hvs1 and 2 except for 16068. Another example occured in SWGDAM, it lacks 16068 transition too.

                    Comment


                    • #11
                      Originally posted by vraatyah
                      That's definitely a L3e although this variant has nothing indicative of subclades. Trovoada recently published several sequences that match both your hvs1 and 2 except for 16068. Another example occured in SWGDAM, it lacks 16068 transition too.
                      Thank you again. Can you direct me to the recently published information on L3e? I find studies placing L3e in Ethiopia and among Yemens is this correct?
                      I also see L3e in Afro- Brazillian and Portuguese. I think I understand the connection.

                      Diane

                      Comment


                      • #12
                        Originally posted by peeceful
                        Thank you again. Can you direct me to the recently published information on L3e? I find studies placing L3e in Ethiopia and among Yemens is this correct?
                        I also see L3e in Afro- Brazillian and Portuguese. I think I understand the connection.

                        Diane

                        The paper you found is Kivisild et al. 2004 article which describes haplogroup motifs by the example of Ethiopian ones. It doesn't mean that all Ls found in Ethiopians are East African in origin, of course. However, the ultimate origin of L3 seems to be prehistoric East African.

                        As to published 16223-16320 sequences, they are mostly West/Central African and African-American.

                        Comment


                        • #13
                          Originally posted by vraatyah
                          That's definitely a L3e although this variant has nothing indicative of subclades. Trovoada recently published several sequences that match both your hvs1 and 2 except for 16068. Another example occured in SWGDAM, it lacks 16068 transition too.
                          Can you please help me with this?
                          When comparing results with someone,
                          what does it mean when the HVR 1 is -3 mutations and HVR2 is -1 mutation.
                          Would there be a common ancestor?

                          Thanks

                          Comment


                          • #14
                            Originally posted by peeceful
                            Can you please help me with this?
                            When comparing results with someone,
                            what does it mean when the HVR 1 is -3 mutations and HVR2 is -1 mutation.
                            Would there be a common ancestor?
                            This question has gone unanswered for a long time, but the answer is almost certainly "no". Four differences is a HUGE amount of difference in mtDNA, genealogically speaking. The probability of a recent common ancestor (i.e. within a couple thousand years) is very low.

                            Comment

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