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  • #1

    Geno 2.0 mtDNA

    I didn't see a Genographic thread and I have lots of questions. I primarily transferred my Geno 2.0 results so I could do Y-DNA STR testing, but it looks from my raw data file that the Geno 2.0 test includes a lot of mtDNA markers. Geno 2.0 shows my mtDNA HG as U4b1b1. When I look at the most current U4b phylogenic tree, there are mutations downstream from U4b1b1 that I have. Did they just quit analyzing at U4b1b1?

    I also cannot find time frames and geographic locations for the established mutations (e.g. u4b1b1). Is it just that no-one has studied this mtDNA HG?

    Also, there are no U HG DNA groups. I was hoping for a U4 group to join.

    There are a couple of the markers that show mutations, and mine are different entirely. e.g. T1193C I think means T is ancestral and C is the mutation. My raw file shows A for 1193. Is this even possible?

    Sorry, but I am somewhat of an amatuer at this and don't understand what I am seeing....
    Tags: geno, genographic, mtdna
  • #2
    There is a U4 haplogroup project, link below. However, Geno 2 mtDNA results are not being transferred correctly to FTDNA, so the project admins will not be able to see your results NG and FTDNA sort out the data transfer.

    http://www.familytreedna.com/public/U4mtDNA

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    • #3
      Originally posted by GST View Post
      There is a U4 haplogroup project, link below. However, Geno 2 mtDNA results are not being transferred correctly to FTDNA, so the project admins will not be able to see your results NG and FTDNA sort out the data transfer.

      http://www.familytreedna.com/public/U4mtDNA
      Thank you! FTDNA did not list any under the mtDNA by letter. I was able to join the U4 group.

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      • #4
        Gene 2.0 Allele values don't seem right

        Gene 2.0 says my mtDNA HG is U4b1b1, but when I look at the allele values in my raw data file, some of them don't match the profile for U4b1b1.

        U4 T4646C mine is C ok
        U4b T7705C mine is C ok
        U4b1 T11339C mine is G but should be C ???
        U4b1b A13528G mine is C but should be G ???
        U4b1b1 C13565T mine is A but should be T ???

        here is the web page I am using:
        http://freepages.genealogy.rootsweb....logeny/U4b.pdf

        Did Geno 2.0 have errors for my alleles, or do I somehow have additional mutations? There are also downstream subclades that I appear to have mutations from the ancestral value. Did Geno 2.0 quit looking after they got to U4b1b1?

        I sent the same questions to them a week ago, but they apparently do not plan to respond. I am not sure if I can believe their results.

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        • #5
          Originally posted by mrmcall3 View Post
          Gene 2.0 says my mtDNA HG is U4b1b1, but when I look at the allele values in my raw data file, some of them don't match the profile for U4b1b1.

          U4 T4646C mine is C ok
          U4b T7705C mine is C ok
          U4b1 T11339C mine is G but should be C ???
          U4b1b A13528G mine is C but should be G ???
          U4b1b1 C13565T mine is A but should be T ???

          here is the web page I am using:
          http://freepages.genealogy.rootsweb....logeny/U4b.pdf

          Did Geno 2.0 have errors for my alleles, or do I somehow have additional mutations? There are also downstream subclades that I appear to have mutations from the ancestral value. Did Geno 2.0 quit looking after they got to U4b1b1?

          I sent the same questions to them a week ago, but they apparently do not plan to respond. I am not sure if I can believe their results.
          It may be that the resource you used (linked to by you) is based on the rCRS reference, which uses H2a2 as the root of the tree. I'm almost sure that Geno 2.0 uses the new RSRS reference, which uses L0 as the root of the tree.

          If that's the case then some of the mutations from H2a2 would not necessarily be a mutation from L0. That would account for the differing base calls that you noted above.

          Comment

          • #6
            Originally posted by mrmcall3 View Post
            Gene 2.0 says my mtDNA HG is U4b1b1, but when I look at the allele values in my raw data file, some of them don't match the profile for U4b1b1.

            U4 T4646C mine is C ok
            U4b T7705C mine is C ok
            U4b1 T11339C mine is G but should be C ???
            U4b1b A13528G mine is C but should be G ???
            U4b1b1 C13565T mine is A but should be T ???

            here is the web page I am using:
            http://freepages.genealogy.rootsweb....logeny/U4b.pdf

            Did Geno 2.0 have errors for my alleles, or do I somehow have additional mutations? There are also downstream subclades that I appear to have mutations from the ancestral value. Did Geno 2.0 quit looking after they got to U4b1b1?

            I sent the same questions to them a week ago, but they apparently do not plan to respond. I am not sure if I can believe their results.
            Geno 2.0 reports some alleles on the "plus" / "forward" strand and others on the "minus" / "reverse" strand. The two strands of the double helix have complementary bases, so A always pairs with T and C always pairs with G. Thus your results are all compatible with U4b1b1.

            With that in mind, you can explore those downstream subclades you saw on the tree. The website you linked to may have assigned its own labels to samples it has on file. The official site is

            http://phylotree.org

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