Haplogroups H6a1a and H6a1b Protected Against Alzheimer's

[Arina92]

H6a1b4 and my maternal grandma had Alzheimers..also, does anyone have some nice resources where i can research some stuff regarding this Haplogroup? It seems like there is so little information about it.

[JTR]

H6a1 seems very Eastern European from what I've been reading. My most distant maternal ancestor was (most likely) German, so I guess that would make sense? I haven't been able to actually connect her back to Germany, but her name was Christiana Dorita Mellick and family tradition said she came from Germany or Holland.

Yes, and the percentages are small for these later lines - which, hopefully, will norrow the geographic region for some of the later SNPs. One of the reasons I got the Geno is that my maternal line is the least developed.

[AlisonT]

H6a1 seems very Eastern European from what I've been reading. My most distant maternal ancestor was (most likely) German, so I guess that would make sense? I haven't been able to actually connect her back to Germany, but her name was Christiana Dorita Mellick and family tradition said she came from Germany or Holland.

[JTR]

Well all the H6-ers show-up, where ya been? I like to know what you have learned about this Hg and specifically the H6a1 people. You guys are the first that I know of and you seem to have been here all along

[jilski]

my dad is H6a1 and according to 23andMe is at a decreased risk for it...

[PDHOTLEN]

Well, it looks like I'm doomed, what with my archaic U5. I once saw an online comment by a respectable-seeming type that U5 (or was it U5b; or was it U5b2) was prone to migraine headaches and still-born babies. My mother experienced both of those. As for my memory, well, it is perceptively less efficient in recent years than formerly. Hmm... (I'm the last of the Paleolithic cave people).

[JuanCarlos]

Well, I'm H6a1a and my mother, who's 87 has a very good memory. Recently, one of her aunts passed away at the age of 106 and her memory was intact. All of her intellectual functioning was good. Another uncle passed away several years ago, at 105 and his memory and awareness of everything were extremely good. She still has another centenarian aunt and her memory is equally good. However, my grandmother, a sister to all of those mentioned, died at 85 and had had Alzheimer's for a long time. They were all H6a1a.

[katerennie4]

Darn, just missed it, I'm H6a2.

[AlisonT]

Well, I just found out I'm H6a1b4, so this is good news for me. :P

[JTR]

"Our findings provide evidence of a reduced risk of AD for individuals with mtDNA haplotypes H6A1A and H6A1B."

The 'Word' police is everywhere.

Changed it - happy!

EDIT: Tried to change it - to late - oh well!

[gtc]

"Our findings provide evidence of a reduced risk of AD for individuals with mtDNA haplotypes H6A1A and H6A1B."

[JTR]

http://www.ncbi.nlm.nih.gov/pubmed/23028804

Enjoy!