Armenian modal haplotype
The most frequent haplotype in a sample of Armenians was seen against the background of HG1 Y chromosomes. It occurred in all Armenian groups, at frequencies ~5-14%. According to YHRD, the same haplotype defined over more loci (14 13 29 24 11 13 12 11,14) was also the most frequent one, occurring in 3% of Armenians (*). According to Whit Athey's haplogroup predictor, this is suggestive of haplogroup R1b.
The geographical distribution of this haplotype is such that it is shared by Armenians and two other populations from the Caucasus. Moreover, it is lacking in most other populations from the Caucasus, as well as in the other populations from further east. On the other hand, it is more frequently found in Europe, where as we know, haplogroup R1b tends to have higher frequencies as well.
The Armenian modal haplotype is also the modal R1b3 haplotype observed by Cinnioglu in Anatolia. According to him, apparently it entered Anatolia from Europe in Paleolithic times, and diffused again from Anatolia in the Late Upper Paleolithic.
An alternative explanation may be that the particular haplotype may have been associated with the movement of the Phrygians into Asia Minor. The Phrygians were an Indo-European people of the Balkans who settled in Asia Minor, and the Armenians were reputed to be descended from them. It would be interesting to thoroughly study the populations of modern Thrace, Anatolia, and Armenia, and to investigate whether a subgroup of R1b3 chromosomes linked by the Armenian modal haplotype may represent the signature of a back-migration into Asia of Balkan Indo-European peoples.
Researching Strong(e)s and Strang(e)s in Britain and Ireland; 2nd Edition (Rootsweb)
BORDER REIVERS DNA STUDY
Although R1b3-M269 lineages are found throughout Europe at considerable frequency (Cruciani et al. 2002), no additional PCR compatible binary markers are currently known that show additional informative subdivision within this clade. However, two TaqI haplotypes ht15 and ht35 associated with the complex RFLP 49a,f locus, are associated with R1b3-M269 lineages. The 49a,f ht15 form is rare in Turkey but common in Iberia (Semino et al. 1996), while 49a,f ht35 representatives are distributed across Europe (Torroni et al. 1990; Santachiara-Benerecetti et al. 1993; Semino et al. 2000b) and occurs at ~10% in the Balkan region (Santachiara-Benerecetti, personal communication). In an attempt to better understand the affinity of the frequent Turkish R1b3-M269 lineages relative to other regions, we have analyzed the same battery of STR loci in 52 additional R1b3-M269 defined samples from Iberia, the Balkans, Iraq, Georgia, and Turkey that were previously determined to be 49a,f ht15 or ht35, as well as an additional 59 European R1b3-M269 derived samples. STR haplotype data for these 111 samples are given in Appendix table B. Principal component analysis of all 187 R1b3-M269 samples at ten STR loci variables reveals distributions coinciding with samples of known 49a,f ht15 and ht35 constitution (Fig. 3). Most of the Turkish samples group with the Balkan and the Caucasian 49a,f ht35 samples, while the West European samples associate with the 49a,f ht15 samples. The variance of 49a,f ht35 related chromosomes are lower in the Balkan, Caucasian and Iraqi representatives than those in Turkey (Table 4). Similarly, the variance is higher in Iberia than in Western Europe. The decreasing diversity radiating from Turkey towards Southeast Europe, Caucasus and Mesopotamia approximates similar results from Iberia tracing the re-colonization of Northwest Europe by hunter-gatherers during the Holocene as suggested by others (Torroni et al. 1998; Semino et al. 2000a; Wilson et al. 2001).
The members of R1b3 (or R-M269, formerly known as R1b) are believed to be the descendants of the first modern humans who entered Europe about 35,000-40,000 years ago ( Aurignacian culture). Those R1b3 forebearers were the people who painted the beautiful art in the caves in Spain and France. They were the modern humans who were the contemporaries - and perhaps exterminators - of the European Neanderthals.
Haplogroup R was the dominant lineage in Western Europe and then, pushed south by the descending Ice Age, to southwestern France and northwestern Spain to evolve into lineage R1b. This area became a refuge for humans in Europe during the coldest millennia of the last Ice Age. As the climate warmed, the scattered clan R1b followed the migration of game to the north and some of them reached what is now the British Isles about 15,000 years ago which at this time was connected to mainland Europe. It is believed they changed from hunter-gatherers to farmers in southeastern Europe about 8,000 years ago and in Britain about 4,000 years ago. As hunter-gathers became farmers permanent settlements ended this great migration period and over time Hg R1b settled predominately in what is known today as Spain, Portugal, France, Belgium, Denmark, England, Wales, Scotland and Ireland.
R1b (previously known as Hg1 and Eu18) is the most prolific haplogroup in Europe and its frequency changes in a cline from west (where it reaches a saturation point of almost 100% in areas of Western Ireland) to east (where it becomes uncommon in parts of Eastern Europe and virtually disappears beyond the Middle East). A R1b haplotype (a set of marker scores indicative of the haplogroup) is very difficult to interpret in that they are found at relatively high frequency in the areas where the Anglo - Saxon and Danish "invaders" originally called home (e.g., 55% in Friesland), and even up to 30% in Norway. Thus a R1b haplotype makes it very challenging to determine the origin of a family with this DNA signature.
R1b probably arrived in Spain from the east 30,000 years ago among the paleolithic or "old stone age" peoples considered to be aboriginal to Europe). It is believed that everyone who is R1b is a descendant in the male line from an individual known as "the patriarch" since his descendants account for over 40% of all the chromosomes of Europe. This haplogroup is characteristic of the Basques whose language is probably that of the first R1b, and who are genetically the closest to the original R1b population (which probably amounted to only a few thousand individuals).
Haplogroup R1b
Haplogroup R was originally the dominant lineage in Western Europe. Geneticists believe that around 18,000 years ago when the last big ice-age was at it's maximum, the people populating Europe at the time (stone-aged hunter-gatherers) had to take refuge away from the ice and retreated back to South-Western France, Spain and Portugal (even though the Pyrenees had thick ice on them).
This area became a refuge for humans in Europe during the coldest millennia of the last Ice Age and evolved into lineage R1b. As the climate warmed, the scattered clan R1b followed the migration of game to the north along the Atlantic coast and some of them reached what is now the British Isles about 15,000 years ago which at this time was connected to mainland Europe. It is believed they changed from hunter-gatherers to farmers in southeastern Europe about 8,000 years ago and in Britain about 4,000 years ago. As hunter-gathers became farmers permanent settlements ended this great migration period and over time Hg R1b settled predominately in what is known today as Spain, Portugal, France, Belgium, Denmark, England, Wales, Scotland and Ireland.
While this migration theory is still being investigated, but the genetic evidence is quite compelling. For those who wish to read up on this further take a look at Semino et al., The Genetic Legacy of Paleolithic Homo Sapiens in Extant Europeans: Science 2000 290: pages 1155-1159.
A summary of the defining characteristics of several other major haplogroups are also shown in Figure 2.
A common subtype of R1b haplotype is the Atlantic Modal Haplotype or AMH that is present primarily along the Atlantic coast in Europe and more specifically with the United Kingdom. AMH previously designated HT1.15 is defined by just 6 markers (alleles) as shown in Figure 2. Because of the high prevalence of AMH among the Irish and Welsh, some researchers consider this haplotype to be representative of the early Celtic migrations and a distinguishing characteristic among the Celts and the Anglo-Saxons.
The members of R1b3 (or R-M269, formerly known as R1b) are believed to be the descendants of the first modern humans who entered Europe about 35,000-40,000 years ago (Aurignacian culture). Those R1b3 forebearers were the people who painted the beautiful art in the caves in Spain and France. They were the modern humans who were the contemporaries - and perhaps exterminators - of the European Neanderthals.
"Today, in Western Ireland, R1b Y-DNA can be found in almost 100% of all males. However the R1b haplotype gradually declines as one moves east from Ireland toward Scandinavia to Eastern Europe where it virtually disappears beyond the Middle East. The vast majority of Northern Europeans are R1b3, defined by marker M269+. The R1b haplotype (a set of marker scores indicative of the haplogroup) is very difficult to interpret because the R1b markers are found at relatively high frequency where the Anglo-Saxon and Danish invaders originally called home. (e.g., 55% in Friesland) and even up to 30% in Norway."
The most frequent haplotype in a sample of Armenians was seen against the background of HG1 Y chromosomes. It occurred in all Armenian groups, at frequencies ~5-14%. According to YHRD, the same haplotype defined over more loci (14 13 29 24 11 13 12 11,14) was also the most frequent one, occurring in 3% of Armenians (*). According to Whit Athey's haplogroup predictor, this is suggestive of haplogroup R1b.
The geographical distribution of this haplotype is such that it is shared by Armenians and two other populations from the Caucasus. Moreover, it is lacking in most other populations from the Caucasus, as well as in the other populations from further east. On the other hand, it is more frequently found in Europe, where as we know, haplogroup R1b tends to have higher frequencies as well.
The Armenian modal haplotype is also the modal R1b3 haplotype observed by Cinnioglu in Anatolia. According to him, apparently it entered Anatolia from Europe in Paleolithic times, and diffused again from Anatolia in the Late Upper Paleolithic.
An alternative explanation may be that the particular haplotype may have been associated with the movement of the Phrygians into Asia Minor. The Phrygians were an Indo-European people of the Balkans who settled in Asia Minor, and the Armenians were reputed to be descended from them. It would be interesting to thoroughly study the populations of modern Thrace, Anatolia, and Armenia, and to investigate whether a subgroup of R1b3 chromosomes linked by the Armenian modal haplotype may represent the signature of a back-migration into Asia of Balkan Indo-European peoples.
Researching Strong(e)s and Strang(e)s in Britain and Ireland; 2nd Edition (Rootsweb)
BORDER REIVERS DNA STUDY
Although R1b3-M269 lineages are found throughout Europe at considerable frequency (Cruciani et al. 2002), no additional PCR compatible binary markers are currently known that show additional informative subdivision within this clade. However, two TaqI haplotypes ht15 and ht35 associated with the complex RFLP 49a,f locus, are associated with R1b3-M269 lineages. The 49a,f ht15 form is rare in Turkey but common in Iberia (Semino et al. 1996), while 49a,f ht35 representatives are distributed across Europe (Torroni et al. 1990; Santachiara-Benerecetti et al. 1993; Semino et al. 2000b) and occurs at ~10% in the Balkan region (Santachiara-Benerecetti, personal communication). In an attempt to better understand the affinity of the frequent Turkish R1b3-M269 lineages relative to other regions, we have analyzed the same battery of STR loci in 52 additional R1b3-M269 defined samples from Iberia, the Balkans, Iraq, Georgia, and Turkey that were previously determined to be 49a,f ht15 or ht35, as well as an additional 59 European R1b3-M269 derived samples. STR haplotype data for these 111 samples are given in Appendix table B. Principal component analysis of all 187 R1b3-M269 samples at ten STR loci variables reveals distributions coinciding with samples of known 49a,f ht15 and ht35 constitution (Fig. 3). Most of the Turkish samples group with the Balkan and the Caucasian 49a,f ht35 samples, while the West European samples associate with the 49a,f ht15 samples. The variance of 49a,f ht35 related chromosomes are lower in the Balkan, Caucasian and Iraqi representatives than those in Turkey (Table 4). Similarly, the variance is higher in Iberia than in Western Europe. The decreasing diversity radiating from Turkey towards Southeast Europe, Caucasus and Mesopotamia approximates similar results from Iberia tracing the re-colonization of Northwest Europe by hunter-gatherers during the Holocene as suggested by others (Torroni et al. 1998; Semino et al. 2000a; Wilson et al. 2001).
The members of R1b3 (or R-M269, formerly known as R1b) are believed to be the descendants of the first modern humans who entered Europe about 35,000-40,000 years ago ( Aurignacian culture). Those R1b3 forebearers were the people who painted the beautiful art in the caves in Spain and France. They were the modern humans who were the contemporaries - and perhaps exterminators - of the European Neanderthals.
Haplogroup R was the dominant lineage in Western Europe and then, pushed south by the descending Ice Age, to southwestern France and northwestern Spain to evolve into lineage R1b. This area became a refuge for humans in Europe during the coldest millennia of the last Ice Age. As the climate warmed, the scattered clan R1b followed the migration of game to the north and some of them reached what is now the British Isles about 15,000 years ago which at this time was connected to mainland Europe. It is believed they changed from hunter-gatherers to farmers in southeastern Europe about 8,000 years ago and in Britain about 4,000 years ago. As hunter-gathers became farmers permanent settlements ended this great migration period and over time Hg R1b settled predominately in what is known today as Spain, Portugal, France, Belgium, Denmark, England, Wales, Scotland and Ireland.
R1b (previously known as Hg1 and Eu18) is the most prolific haplogroup in Europe and its frequency changes in a cline from west (where it reaches a saturation point of almost 100% in areas of Western Ireland) to east (where it becomes uncommon in parts of Eastern Europe and virtually disappears beyond the Middle East). A R1b haplotype (a set of marker scores indicative of the haplogroup) is very difficult to interpret in that they are found at relatively high frequency in the areas where the Anglo - Saxon and Danish "invaders" originally called home (e.g., 55% in Friesland), and even up to 30% in Norway. Thus a R1b haplotype makes it very challenging to determine the origin of a family with this DNA signature.
R1b probably arrived in Spain from the east 30,000 years ago among the paleolithic or "old stone age" peoples considered to be aboriginal to Europe). It is believed that everyone who is R1b is a descendant in the male line from an individual known as "the patriarch" since his descendants account for over 40% of all the chromosomes of Europe. This haplogroup is characteristic of the Basques whose language is probably that of the first R1b, and who are genetically the closest to the original R1b population (which probably amounted to only a few thousand individuals).
Haplogroup R1b
Haplogroup R was originally the dominant lineage in Western Europe. Geneticists believe that around 18,000 years ago when the last big ice-age was at it's maximum, the people populating Europe at the time (stone-aged hunter-gatherers) had to take refuge away from the ice and retreated back to South-Western France, Spain and Portugal (even though the Pyrenees had thick ice on them).
This area became a refuge for humans in Europe during the coldest millennia of the last Ice Age and evolved into lineage R1b. As the climate warmed, the scattered clan R1b followed the migration of game to the north along the Atlantic coast and some of them reached what is now the British Isles about 15,000 years ago which at this time was connected to mainland Europe. It is believed they changed from hunter-gatherers to farmers in southeastern Europe about 8,000 years ago and in Britain about 4,000 years ago. As hunter-gathers became farmers permanent settlements ended this great migration period and over time Hg R1b settled predominately in what is known today as Spain, Portugal, France, Belgium, Denmark, England, Wales, Scotland and Ireland.
While this migration theory is still being investigated, but the genetic evidence is quite compelling. For those who wish to read up on this further take a look at Semino et al., The Genetic Legacy of Paleolithic Homo Sapiens in Extant Europeans: Science 2000 290: pages 1155-1159.
A summary of the defining characteristics of several other major haplogroups are also shown in Figure 2.
A common subtype of R1b haplotype is the Atlantic Modal Haplotype or AMH that is present primarily along the Atlantic coast in Europe and more specifically with the United Kingdom. AMH previously designated HT1.15 is defined by just 6 markers (alleles) as shown in Figure 2. Because of the high prevalence of AMH among the Irish and Welsh, some researchers consider this haplotype to be representative of the early Celtic migrations and a distinguishing characteristic among the Celts and the Anglo-Saxons.
The members of R1b3 (or R-M269, formerly known as R1b) are believed to be the descendants of the first modern humans who entered Europe about 35,000-40,000 years ago (Aurignacian culture). Those R1b3 forebearers were the people who painted the beautiful art in the caves in Spain and France. They were the modern humans who were the contemporaries - and perhaps exterminators - of the European Neanderthals.
"Today, in Western Ireland, R1b Y-DNA can be found in almost 100% of all males. However the R1b haplotype gradually declines as one moves east from Ireland toward Scandinavia to Eastern Europe where it virtually disappears beyond the Middle East. The vast majority of Northern Europeans are R1b3, defined by marker M269+. The R1b haplotype (a set of marker scores indicative of the haplogroup) is very difficult to interpret because the R1b markers are found at relatively high frequency where the Anglo-Saxon and Danish invaders originally called home. (e.g., 55% in Friesland) and even up to 30% in Norway."
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