Originally posted by Ann Turner
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Inbreeding impact on Y chromosome?
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Thank you Ann!
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Cheers.
Originally posted by Javelin View PostNo, just trying to understand what you mean. The Y can be affected by inbreeding at a population level (drift as Ann outlines), but not at an individual level.
So, it appears that inbreeding does not affect Y mutation rates. Is there anything that COULD (at a GD=15) in a 400 year period and still reconcile with the same MRCA?
Cheers.
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Originally posted by Zaru View PostThat's not the entirety of the study though. It also discusses the impact that inbreeding has genetically on individuals as expressed in the intro:
"The study of inbreeding, the consequence of mating with relatives, has an important place in genetics.The similarity of the paternal and maternal contributions caused by the mating of relatives leads to increased homogeneity of inbred individuals."
I am not maintaining that Y is affected in inbreeding, I am only asking if it is possible.
Cheers.
The child of first cousins would have more markers that are "homozygous" on the Family Finder test. This only matters if the DNA fragment in the grandparent already has a harmful mutation. Inbreeding per se does not increase the mutation rate (although I suppose there might be a gene that influences the mutation rate).
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Originally posted by Zaru View PostDoes inbreeding have an impact on mutation rates for the Y chromosome? The parents in question were first cousins.
Cheers,
Rosario
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Originally posted by Zaru View PostYou are coming across as being condescending. I hope that is not your purpose
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Thank you for your response.
Originally posted by Ann Turner View PostThe linked paper is not talking about mutations or mutation rates. It's talking about a process called genetic drift, which applies to populations. For example, suppose two villages both start out with 40% of the people having blood type A. After one hundred years of marriages within their own village, 55% of the people in one village might have blood type A, while 34% of the people in the other village have blood type A. The percentages have drifted away from the starting point. This is just a random change, depending on how many children happened to be born to parents with blood type A compared to other blood types.
"The study of inbreeding, the consequence of mating with relatives, has an important place in genetics.The similarity of the paternal and maternal contributions caused by the mating of relatives leads to increased homogeneity of inbred individuals."
I am not maintaining that Y is affected in inbreeding, I am only asking if it is possible.
Cheers.
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Originally posted by Zaru View PostMy question is whether or not an inbreeding scenario could cause a quicker mutation rate on any loci as a result of the event? The linked paper caused confusion for me.
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Originally posted by Javelin View PostIf a mother has no Y, how is her relatedness to the father supposed to affect the Y's mutation rates?Last edited by Zaru; 4 November 2011, 06:36 PM.
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If a mother has no Y, how is her relatedness to the father supposed to affect the Y's mutation rates?
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Originally posted by Javelin View PostDo you mean something like "rates or variation in the Y chromosome in a population" rather than "one individual's Y"?
My question is whether or not an inbreeding scenario could cause a quicker mutation rate on any loci as a result of the event? The linked paper caused confusion for me.
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Do you mean something like "rates or variation in the Y chromosome in a population" rather than "one individual's Y"?
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Originally posted by k.o.gran View PostHi Rosario,
As the mother does not carry the Y-chromosome, I can't see how it could be affected in that scenario.
-Kai
In 1951, the geneticist Luigi Luca Cavalli-Sforza was teaching in Parma when a student--a priest named Antonio Moroni--told him about rich church records of demography and marriages between relatives. After convincing the Church to open its records, Cavalli-Sforza, Moroni, and Gianna Zei embarked on a landmark study that would last fifty years and cover all of Italy. This book assembles and analyzes the team's research for the first time. Using blood testing as well as church records, the team investigated the frequency of consanguineous marriages and its use for estimating inbreeding and studying the relations between inbreeding and drift. They tested the importance of random genetic drift by studying population structure through demography of the last three centuries, using it to predict the spatial variation of frequencies of genetic markers. The authors find that drift-related genetic variation, including its stabilization by migration, is best predicted by computer simulation. They also analyze the usefulness and limits of the concept of deme for defining Mendelian populations. The genetic effect of consanguineous marriage on recessive genetic diseases and for the detection of dominance in metric characters are also studied. Ultimately bringing together the many strands of their massive project, Cavalli-Sforza, Moroni, and Zei are able to map genetic drift in all of Italy's approximately 8,000 communes and to demonstrate the relationship between each locality's drift and various ecological and demographic factors. In terms of both methods and findings, their accomplishment is tremendously important for understanding human social structure and the genetic effects of drift and inbreeding.
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Originally posted by Zaru View PostDoes inbreeding have an impact on mutation rates for the Y chromosome? The parents in question were first cousins.
As the mother does not carry the Y-chromosome, I can't see how it could be affected in that scenario.
-Kai
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Inbreeding impact on Y chromosome?
Does inbreeding have an impact on mutation rates for the Y chromosome? The parents in question were first cousins.
Cheers,
RosarioTags: None
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