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mtDNA Haplogroup H

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  • mtDNA Haplogroup H

    Well, it's pretty straightforward at this point, but I still don't quite "get" it. I got the Haplogroup H with no subclades and it seems only one mutation---16519C. Is that correct? Nothing else on the certificate for the HVR1 and the HVR2 isn't complete as they ran into problems. So, how do I interpret this. It's just so "H" and that's it.

  • #2
    I believe that H is the most common in Europe and not many variations for it.
    It is so wide spread that it has limited meaning unlike the subclades of Y DNA.

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    • #3
      Janelle, I had the same plain H until I got the mitFGS; HVR-1 I had 9000 matches. Had to do something about that. HVR-2 still had 400+.

      Finally with the mitFGS I found out we're in an obscure little group, H16, and it narrowed down to two matches. Probably you are not just plain H. And be glad, LOL.

      Aren't they going to rerun your sample, if they ran into problems?

      Here's my differences:
      Haplogroup - H16

      HVR1 differences from CRS
      16519C
      HVR2 differences from CRS
      152C
      263G
      315.1C
      CR differences from CRS
      750G
      1438G
      4769G
      8860G
      10394T
      14155T
      14869C
      15326G



      P.S. Here's some groups you could be (wiki):

      H1, H2, H3, H4, H5'36, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, H16, H18, H19, H20, H22, H23, H24, H25, H26, H28, H29, H31, H32, H33, H34, H35, H37, H38, H39

      Try to get into your subgroup project; there is even one for our small group H16.
      Last edited by Wilma Wildcat; 21 July 2011, 08:29 AM.

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      • #4
        Originally posted by Janelle View Post
        Well, it's pretty straightforward at this point, but I still don't quite "get" it. I got the Haplogroup H with no subclades and it seems only one mutation---16519C. Is that correct? Nothing else on the certificate for the HVR1 and the HVR2 isn't complete as they ran into problems. So, how do I interpret this. It's just so "H" and that's it.
        You'll have to wait until they verify what your values are for HVR2. You *might* be able to make an educated guess on your subclade once you get those results. After they come in, check your "haplogroup origins" on the left side of your home page, and perhaps after the generic H's you'll see matches that all belong to a particular subclade, based on your HVR2 values. You should also join the H Project for additional help. The only way to definitively know your subclade is to have the FGS done.
        Last edited by vinnie; 21 July 2011, 09:27 AM.

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        • #5
          Wow. I wasn't aware of these subgroups because I only had the panel one and two. Do these groups roughly indicate geographical locations in the same general way that y DNA does?

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          • #6
            Originally posted by Brunetmj View Post
            Wow. I wasn't aware of these subgroups because I only had the panel one and two. Do these groups roughly indicate geographical locations in the same general way that y DNA does?
            They are some published papers on H, and I believe Dr. Behar is working on it - he was collecting H FGS results a while back. But I can see the difference in distribution between the subclades by comparing my H results with a friend's. He's most likely H6 (based on his HVR values and his matches on his haplogroup origins page) and has a lot of matches in Western Europe, particularly Switzerland. My confirmed H7 also as a lot of WE (none from Switzerland), but I've also got a lot from Portugal, Eastern Europe, and some from North Africa which he doesn't.

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            • #7
              Hi. Although I have U5, my HVR1 has only 16270 & 16519. When I look at Mitosearch, there is a whole page of H with only 16519; as minus 1 as to a match. There are even several H with both 16270 & 16519, which makes them look like U5. So the bottom line is, have your FGS test done if you can possibly afford it.

              Best

              Phil Hotlen

              Comment


              • #8
                My wife's was the same: 16519C at HVR1, predicted H. When she upgraded to FGS, it was confirmed at H3. She went from over 9000 matches at HVR1 to about 1400 matches at HVR2, down to 3 matches at FGS.

                Originally posted by Janelle View Post
                Well, it's pretty straightforward at this point, but I still don't quite "get" it. I got the Haplogroup H with no subclades and it seems only one mutation---16519C. Is that correct? Nothing else on the certificate for the HVR1 and the HVR2 isn't complete as they ran into problems. So, how do I interpret this. It's just so "H" and that's it.

                Comment


                • #9
                  You can refine the subclade of your mtDNA haplogroup using James Lick's mtDNA Haplogroup Analysis tool. You'll need to download the FASTA file with the raw data from your mtDNA test first.

                  Comment


                  • #10
                    Originally posted by Wilma Wildcat View Post
                    Janelle, I had the same plain H until I got the mitFGS; HVR-1 I had 9000 matches. Had to do something about that. HVR-2 still had 400+.

                    Finally with the mitFGS I found out we're in an obscure little group, H16, and it narrowed down to two matches. Probably you are not just plain H. And be glad, LOL.

                    Aren't they going to rerun your sample, if they ran into problems?

                    Here's my differences:
                    Haplogroup - H16

                    HVR1 differences from CRS
                    16519C
                    HVR2 differences from CRS
                    152C
                    263G
                    315.1C
                    CR differences from CRS
                    750G
                    1438G
                    4769G
                    8860G
                    10394T
                    14155T
                    14869C
                    15326G



                    P.S. Here's some groups you could be (wiki):

                    H1, H2, H3, H4, H5'36, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, H16, H18, H19, H20, H22, H23, H24, H25, H26, H28, H29, H31, H32, H33, H34, H35, H37, H38, H39

                    Try to get into your subgroup project; there is even one for our small group H16.
                    That was very encouraging. Thanks. They are currently running the HV2 and I should get that the first week in August. So, perhaps I should up the ante and go for the mtFGS. They had a special at one point, that I ignored, but maybe next time I won't. Thanks.

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                    • #11
                      All of the responses have been helpful. When I find something else out, I'll post it. Thanks again.

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                      • #12
                        Well even if you do the FGS, you still may not get a subclade. I am still an H, though at least they removed the *. I have 5 mutations at HVR1 with 3 matches. I have 2 mutations at HVR2 with 2 matches(2 from the previous HVR1 matches). I have an additional 7 mutations with my FGS & have 1 match, but we could not find a common ancestress/surname. Dr. Behar requested my FGS some time ago & I sent it. One of these days...

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                        • #13
                          I've had all of the mtDNA tests done, I'm H1. I have nearly 9,000 HVR1 matches, none for HVR2 and none for the FGS.....maybe one day I will see a HVR2 match...

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                          • #14
                            Haplogroup H

                            My dad's results came back for his mtDNA as Haplogroup H, I couldn't believe all the matches, crazy, compared to my own Haplogroup B, I have 6 HV1 matches and 2 HV 2 matches, but Haplogroup H has almost 2000 matches for him.
                            Thanks for all the advice everyone has given to the original poster, I was getting ready to ask the same questions.

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                            • #15
                              I meant 9620 low resolution matches
                              and 1820 HV2 matches
                              Last edited by deniseneufeld; 22 July 2011, 10:19 PM.

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