Snpedia and FGS Results

[Elistariel]

Does anyone know how the devil to use this website? I just learned that one's FGS results can have info on health issues. (Or something like that). I search for my mutations, 1438G for example and it gives me some rs6311 crap with what looks like an algebra equation to me.
I searched 1438G and this is part of what I got:

"rs6311 (-1438A>G / A-1438G or -1438G>A / G-1438A) is a SNP located upstream (and within the promoter region of) HTR2A.

[PMID 16814396] Three (rs643627-rs594242-rs6311: A-C-T), two (rs594242-rs6311: C-T) and a single functional (rs6311: T) marker were protective against suicidal behavior. The complementary makers (rs594242-rs6311: G-C and rs6311: C) were associated with increased risk for non-violent and impulsive suicidal behavior. Furthermore, CC-homozygotes for the functional SNP rs6311 reported more anger- and aggression-related behavior."

What the ...?!
To me that says rs6311 times (negative1438A is greater than A minus 1438G OR negative 1438G is greater than A divided by G minus 1438A)
That... can NOT be right.
And what is that PMID thing?

HELP?!
I feel like I'm trying to read Klingon.

[gtc]

I had a look at that and other sites and opted to let Ann Turner interpret it all for me (for a small fee).

[Carolyn1955]

How does one contact Ann Turner? I'd like her to take a look at my FGS results. Seems it would be worth a small fee.

I had a look at that and other sites and opted to let Ann Turner interpret it all for me (for a small fee).

[gtc]

How does one contact Ann Turner? I'd like her to take a look at my FGS results. Seems it would be worth a small fee.

Email her at [email protected] and she will reply with a service information sheet.

[Elistariel]

If it costs money, I can't do it.

[Bill Hurst]

Hi Elistariel and all,

1438G is found in just about everybody any distance away from the CRS.

Bill Hurst

[gtc]

I have it, and I haven't hung myself yet :-)

[Elistariel]

On another note, how does one get a hold of one's raw data? How do I find out what rs1234 thing my 1234A or whatever is.

[vinnie]

Hi Elistariel,

You may want to remove your CR results from your Forum signature, just in case any of those mutations have medical implications. Once you remove them using Edit Signature, they'll be deleted from all your previous Forum postings. There's no problem with posting HVR1 & 2 results. As for your full results, they're normally accessed by a FASTA file link in your Results page, but the links have been temporarily removed as FTDNA upgrades its website security. By the way, Ann Turner quoted me a very reasonable charge for her work.

Vinnie

[Elistariel]

Hi Elistariel,

You may want to remove your CR results from your Forum signature, just in case any of those mutations have medical implications. Once you remove them using Edit Signature, they'll be deleted from all your previous Forum postings. There's no problem with posting HVR1 & 2 results. As for your full results, they're normally accessed by a FASTA file link in your Results page, but the links have been temporarily removed as FTDNA upgrades its website security. By the way, Ann Turner quoted me a very reasonable charge for her work.

Vinnie

Doesn't bother me. If I have a gene for a medical condition that doesn't mean I will have said medical condition. Besides having something medically "wrong" with someone doesn't make them a bad person. I'm leaving it. If someone wants to judge me for a gene I have, that's their problem, not mine.
Besides I can't even figure out what the heck those are genes for.
All I've found is something for suicidal tendencies and rheumatoid arthritis, neither of which I or anyone in my family has.

[rucksack]

You can check this.

MITOMAP
A human mitochondrial genome database
A compendium of polymorphisms and mutations of the human mitochondrial DNA

http://www.mitomap.org/bin/view/MITOMAP

Search on that page for this mtDNA Mutations with Reports of Disease-Associations

[gtc]

If I have a gene for a medical condition that doesn't mean I will have said medical condition.

That's right.

[vinnie]

Yes, that's true, but so is the reverse. Likewise, Ann Turner pointed out to me that our FGS results are shared by every member of our family who's related on our direct maternal line. As such, privacy issues do not concern just those of us who test, but all who could be affected by the results being made public. While we're each free to do what we want with our results, clearly this area of genetic genealogy calls for some ethical introspection.

[Bill Hurst]

Hi all,

I don't disagree about not publishing your FGS results on your signature, etc. Put them on GenBank anonymously. Make sure you haplogroup project administrator can see them.

But to the original idea that 1438G has some relationship to suicidal behavior, it has about the same relationship as "Flash! Scientists find that most of those with suicidal behavior have two arms."

Bill Hurst

[Elistariel]

Yes, that's true, but so is the reverse. Likewise, Ann Turner pointed out to me that our FGS results are shared by every member of our family who's related on our direct maternal line. As such, privacy issues do not concern just those of us who test, but all who could be affected by the results being made public. While we're each free to do what we want with our results, clearly this area of genetic genealogy calls for some ethical introspection.

Here, let me tell you the name of every person on my mother's mother's side...
Common decency tells you that you don't tell people the names of living family members when you do genealogy online.
Heck, the gene I COULD be carrying a gene for a rare disease isn't even mentioned on the snpedia site. (I have a cousin with it and another cousin who probably had it and passed away before I was even born.) - No I won't tell you what it is, but it's really rare. Both cousins had the same mtDNA as me.