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  • Eye color...

    I just got my results back from 23andme. (Which by-the-way was completed in 2 weeks or less).
    I have hazel eyes, just as you describe your own, green band around the outside of the iris and a bit of brown toward the pupil, olive green with small flecks of brown and green. They have me listed as likely to have brown eyes. My mother had dark brown eyes, as did her mother. But my great grandmother (whom I knew well) had blue eyes. My father had blue eyes as did his mother. My brother and sister both have dark brown eyes.
    I'm also the only blond in the family, with very light skin, some freckles and a sun allergy. Not much malanin.

    The other thing they were dead wrong about is the likelihood to "flush" with alcohol. There was a recent study about Asians and flushing and having that trait increased the likelihood of getting esophogeal cancer. I'm not Asian, I do flush terribly from any form of alcohol even a sip of wine. I can't drink red wine at all due to the severe headaches. Histamine reaction. Any kind of emotion like anger, embarrassment, or even flirting causes the same flush. Bright red across my cheeks (like blushing) down my neck and across my chest. I was told decades ago that my paternal aunt had the same reactions.

    In general I'm disappointed by 23andme. I tested with ftDNA years ago and have upgraded to FGS. I haven't been disappointed there. I'm haplo HV1 - which 23andme doesn't even call by name. (Just a sub-group of H) I've been in contact with other FGS matches who have done further interviews, research and we keep in touch regularly. It's been quite interesting. There are very few matches at that level and our ancestors all lived within about 75 -100 miles of each other in an area of Eastern Europe. So there is a strong feeling of "relatedness" (if that's a word). We all found that we were writers or journalists or people who love to talk and communicate.
    I wish 23and me would include questions that take "profession" or "hobbies" into account. It took years of just learning about what all the statistical data means at ftDNA. Not that I do even now.... but at 23andme, I don't feel "connected" to anyone else. I don't see much data. At least not yet.
    I DO like see the possible medical implications. My mother died of a rare kind of Parkinsons and I really, truly needed to know if there were odds that it was in my future. I'm happy to know that I have just the normal risk factors for getting Parkinsons and not the markers for it. But I believe we haven't seen the majority of illness and risk markers yet.
    Essentially I think 23andme needs to stop pandering just to the people who want to know about disease and they should get their act together about ancestry and genetics. They should do both.

    Comment


    • Hi Radio1,
      It's interesting to read your views on the test. Although, I have not done the 23andme test, I have come to the decision that each test has it's limitations and it's benefits.
      I am very impressed by DeCodeMe's map of kinship, which seems to place people nicely next to populations where they do actually come from and from this I do think that I have some Eastern European ancestry.
      This also ties in with AbDNA and DNATribes results (see signature). What I'm not so impressed with, is the confusion between MtDNA results, but different companies use different methods and these companies specialise more in health than ancestry. I think they should be more user friendly also.
      As for the flushing you mention, it could be an allergy. Me and my mother are the same, and assumed as we had East Asian results with AbDNA, it must be Asian flush, but according to DeCode, we don't have the gene, so it must be an allergy. But you have Eastern European ancestry which is interesting...whereabouts were your ancestors from? Was it invaded by Ghengis Khan? I know it was a long time ago, but maybe there is a tendency to be more prone to alcohol allergies in people with distant East Asian admixture?
      Last edited by burto; 3 May 2009, 06:41 AM.

      Comment


      • Asian Flush

        burto;

        You're probably dead on correct about that..... on my mitachondria side there is an ancestor who I was actually name for, my g-grandfather who looked asian. I'm told his cheekbones were high and he had asian/almond shaped eyes whose people were from the "Mongol region". He died the year before I was born. He met and married his wife my g-grandmother in an area of Russis that had previously been Lithuania, near Minsk. But they say he looked very asian. My mother got his high cheekbones and almond shaped eyes, she was a pretty woman.
        But my mother never had the "flush" nor did anyone I know of in my mother's family. It was my fathere's sister who had the same flushing at alcohol and emotions. Hystamine reaction, they call it. I don't even have to drink anything to flush like that. I just have to get mad, or embarrassed. I assumed it was tied to my fair complexion.

        Comment


        • More 23andme stuff

          Sorry to follow my own post, but I was hoping for a bit more disc ussion about the 23andme site. As I posted previously, I got my results in less than 2 weeks, but am still struggling to decifer the meaning. On the surface, it's deceptively simple. They sort of emphasize the medical aspects, the chances or odds of getting a disease or trait due to the presence of certain markers. That's why I did the additional testing with them, I wanted more than I could easily find at FTdna. But now that I'm getting used to their information, I'm finding it difficult to find other people with my haplogroup, their message board (if you can even call it that) has no navigation tools or edit functions. They provide raw data which is great, but I'm not a scientist and can't extrapolate anything from it unless I know specifically what I'm looking for - which I don't. I'm an amateur. I do something else for a living. My assumption is that I pay the fee these services provide and they should connect the dots for me. Perhaps I'm wrong to think that way.
          What do you all think of 23andme compared and contrasted with FTdna?

          Comment


          • More 23andme stuff

            Sorry to follow my own post, but I was hoping for a bit more discussion about the 23andme site. I got my results in less than 2 weeks, but am still struggling to decipher the extent of the testing. It appears deceptively simple, at first glance. They sort of emphasize the medical aspects, i.e. the likelihood of getting a disease or trait due to the presence (or absence) of certain markers. That's why I did the additional testing with them, I wanted more than I could easily find at FTdna. Now that I've had a few days to get used to their stie, I'm noticing that it's difficult to find other people with my haplogroup. And their message boards (if you can even call it that) has no navigation tools or edit functions. They do provide raw data, which is great, but I'm not a scientist and can't extrapolate anything from it unless I know specifically what I'm looking for - which I don't. I'm an amateur. I do something else for a living. My assumption is that I pay the fee these services provide and they should connect the dots for me. Perhaps I'm wrong to think that way.
            What do you all think of 23andme compared and contrasted with FTdna?

            Comment


            • I just ordered my 23andMe kit finally! Hopefully I will receive some interesting and inciting results.

              Comment


              • Gene2005

                23andme acknowledges that they're not very good about noting native american tribes, they are all listed as Asian instead. I didn't read anything about African American results that they posted, but clearly if they can't get the results narrowed down for an indiginous group of people like the American Indians, then I don't trust them to clearly define and delineate African Americans who may have European genes, African genes, Asian genes, Native American genes or any other conceivable mix considering the long route from the African continent.
                They state that they hope to have many changes in that regard within the next 6 months to a year. I would certainly hope so.
                Did you find that any of their studies, reports and clinical analyses were helpful?

                Comment


                • epigenome

                  No, I haven't tested with 23andme.

                  What a lot of people wonder and worry about, healthwise, isn't just from the genome, but also the epigenome.

                  http://www.pbs.org/wgbh/nova/genes/

                  "Identical genes active in one twin maybe shut down in the other. Thus, as the years pass, epigenetic changes accumulate in twins, as in the rest of us."

                  Here is the transcript of the NOVA tv show that aired on pbs.
                  http://www.pbs.org/wgbh/nova/transcr...413_genes.html
                  Last edited by rainbow; 21 May 2009, 01:16 PM.

                  Comment


                  • Hi. I ordered 23andme and my results are in. I hope to read my Ancestry Painting/admixture results this weekend on a regular computer that has JavaScript. My cellphone has web access but my browser doesn't have JavaScript and can't download it. What I have been able to read so far is that my MTDNA is H1*. I can view parts of Browse Raw Data (except for all the question mark icons. I notice three questim marks below each chromosone and assume it is the percentages that I can't read), but I don't know how to interpret it.

                    I read in the New Tribes Populations thread that 23andme is going to have 6 North American Indian categories/groups to compare with. Right now I think they still have only Japanese and Chinese to compare to. If 23andme says they found some East Asian ancestry in my genome, then I will compare my data with the new North American Indian data. In 2006 I tested with DNAPrint and my AncestryByDna 2.5 result was 83% European and 17% Native American. That was unexpected.

                    Comment


                    • Originally posted by rainbow View Post
                      Hi. I ordered 23andme and my results are in. I hope to read my Ancestry Painting/admixture results this weekend on a regular computer that has JavaScript. My cellphone has web access but my browser doesn't have JavaScript and can't download it. What I have been able to read so far is that my MTDNA is H1*. I can view parts of Browse Raw Data (except for all the question mark icons. I notice three questim marks below each chromosone and assume it is the percentages that I can't read), but I don't know how to interpret it.

                      I read in the New Tribes Populations thread that 23andme is going to have 6 North American Indian categories/groups to compare with. Right now I think they still have only Japanese and Chinese to compare to. If 23andme says they found some East Asian ancestry in my genome, then I will compare my data with the new North American Indian data. In 2006 I tested with DNAPrint and my AncestryByDna 2.5 result was 83% European and 17% Native American. That was unexpected.
                      Rainbow, go to the left side of the page and click on "Ancestry Painting". This is the single most important feature in order to compare your DNAPrint score with that from 23andMe. It will be interesting to see the results from 23andMe which is far more conservative. You will have a percent European, Asian and African.

                      I am the one who "gathered" the Native Americans from North America. The results are not going to be used by 23andMe in their analyses as far as I know. The data will be collected by myself and those I am working with and perhaps we can set up a matching program to look for sequences in common on the autosomes and the X chromosome. There will be no charge for this, and at this moment I have no idea exactly how this will all come about. Perhaps I can enlist the assistance of individuals such as Dr. McDonald who is doing this sort of work now with the 52 populations of the HGDP-CEPH panel. I expect that he could incorporate the new samples as reference individuals for North American. I am just wrapping up the part where I ensure that the kits are on their way - a great deal of work went into the screening part to ensure that all individuals are "status" members of a First Nations band, and have Native American on both sides of the family.

                      DKF.

                      Comment


                      • Originally posted by rainbow View Post
                        Hi. I ordered 23andme and my results are in. I hope to read my Ancestry Painting/admixture results this weekend on a regular computer that has JavaScript. My cellphone has web access but my browser doesn't have JavaScript and can't download it. What I have been able to read so far is that my MTDNA is H1*. I can view parts of Browse Raw Data (except for all the question mark icons. I notice three questim marks below each chromosone and assume it is the percentages that I can't read), but I don't know how to interpret it.

                        I read in the New Tribes Populations thread that 23andme is going to have 6 North American Indian categories/groups to compare with. Right now I think they still have only Japanese and Chinese to compare to. If 23andme says they found some East Asian ancestry in my genome, then I will compare my data with the new North American Indian data. In 2006 I tested with DNAPrint and my AncestryByDna 2.5 result was 83% European and 17% Native American. That was unexpected.
                        Remember, with 23andMe ANY "Asian" on a generally European background may be significant - even < 1% - due to the conservative nature of their algorithm (definitiions), and the fact that if one is searching for Native American, being compared to the Chinese Han is to some degree debatable.

                        Comment


                        • The new North American Indian data won't be in 23andme? That is disappointing. I thought I was dreaming, guess I was.

                          If any North American Native Americans want to add their str markers to DNATribes, please do. Pretty please with sugar on top, with a cherry. The person who works there that answered my gazillion DNATribes questions is Lucas Martin. Hmm, I wonder if he is related to FTDNA's Darren Martin, who has also answered a bunch of my FTDNA questions. The email address
                          is [email protected].


                          If not late afternoon today, maybe I will read my 23andme sometime Monday afternoon, up to about 8pm.
                          Last edited by rainbow; 17 October 2009, 11:58 AM.

                          Comment


                          • Originally posted by rainbow View Post
                            The new North American Indian data won't be in 23andme? That is disappointing. I thought I was dreaming, guess I was.

                            If any North American Native Americans want to add their str markers to DNATribes, please do. Pretty please with sugar on top, with a cherry. The person who works there that answered my gazillion DNATribes questions is Lucas Martin. Hmm, I wonder if he is related to FTDNA's Darren Martin, who has also answered a bunch of my FTDNA questions. The email address
                            is [email protected].


                            If not late afternoon today, maybe I will read my 23andme sometime Monday afternoon, up to about 8pm.
                            Yes, it will be in the 23andMe database, but you will have to request genome sharing by invitation. However if there is a match it will automatically show in Relative Finder, the newest feature. However you still have to contact the person and request a sharing - look for a NA mtDNA and Y DNA as a signal that this may be one of the people I and others recruited (plus a very few already in the databases). "My" lot will not likely appear for a couple of months - but again, if they match, you will see them as 5th cousins, 6th cousins or whatever. This won't mean much until the feature goes alpha and released to all.

                            Comment


                            • I just read my Ancestry Painting result.


                              Europe >99%
                              Africa <1%
                              Asia 0%


                              There is a bit of green (Africa) on the top half of Chromosone #3 and the top of chromosone #5.
                              I downloaded my data from the Browse section, but it won't open. Saved it again in wordpad. My wordpad and notepad are unresponsive.


                              Why does every test I take say something different?
                              AncestryByDna 2.5 from DNAPrint said I'm 83% European and 17% Native American. I have had many updates from DNATribes and keep getting odd matches.

                              Comment


                              • Originally posted by rainbow View Post
                                I just read my Ancestry Painting result.


                                Europe >99%
                                Africa <1%
                                Asia 0%


                                There is a bit of green (Africa) on the top half of Chromosone #3 and the top of chromosone #5.
                                I downloaded my data from the Browse section, but it won't open. Saved it again in wordpad. My wordpad and notepad are unresponsive.


                                Why does every test I take say something different?
                                AncestryByDna 2.5 from DNAPrint said I'm 83% European and 17% Native American. I have had many updates from DNATribes and keep getting odd matches.
                                That is very frustrating. On the up side, I think that it is safe to say that your Colonial heritage incudes some contribution from Africa - Asian is more difficult to interpret (e.g., unlikely, but could be Crimean Tartar or Ukrainian - Polish Avar).

                                Again we get back to the "why 17% NA in the DNAPrint test"? I don't think that one can offer a clear cut answer. You may yet find that in addition to some African, that with new additions to the database and with an algorithm that does not use the Chinese Han as a proxy for Native American (coming soon at 23andMe???), some degree of NA will surface. However it is unlikely to be anywhere near 17%. Many people with NA on both sides of their family via 23andMe do not show anywhere near 17% - that number seems to be greatly inflated. If you look at the confidence intervals (two circles) around the red dot, and one or both reach zero, it means that in addition to their best guestimate of 17%, zero is among the possibilities - just less likely. Alas the test was so flawed from the git go that I really don't know what to do with my own data and that of family members.

                                If you wish to share with me so I can see in general the specifics you can send an invitation to fauxdk.

                                Comment

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