X chromosome ancestry testing: Selecting the right candidate

[tomcat]

...
This makes it very clear that the best person for me to test to find information relating to my gg grandmother Hannah (Young) Dawson, and hence my Loyalist German and Six Nations Mohawk heitage (helped by the fact that her parents were first cousins), is my mother's brother.....

Thought you were Canadian Mohawk? Canadian Mohawk were clients of the French who were enemies of the south-of-the-Saint-Lawrence-Mohawk (NY state). Was the Canadian branch even part of the Iroquois Confederacy?

[Kathleen Carrow]

Becasue its cross validation for DeCodeMe. I was given a 6% overall Asian ( result on autosomal and a 9% overall Asian result on x...I want to see what 23andme gives me...I know that DeCodeMe is more generous with their ethnic percentages..Want to see if its true, if both DeCodeme and 23andme are close in percentages than its probably correct...Since its only 400.00, why not...
For instance when you open the genome browser and you highlight Chromosome x down below it says my ancestry you have a graph. Yellow represents Asian. If you run the cursor across the whole length of the graph you will get different percentages for Asian. I get anywhere from 1.90% to 48.60% on my X chromosome...I guess they settled for 9% as a comprimise...

Maria

Well that makes sense..Good idea..

[DKF]

Just a reminder that it is important to know whose ancestral contribution will be registered on your X. Blaine Bettinger just published fan charts which include specific percentages:

http://www.thegeneticgenealogist.com...mosome-charts/

This makes it very clear that the best person for me to test to find information relating to my gg grandmother Hannah (Young) Dawson, and hence my Loyalist German and Six Nations Mohawk heitage (helped by the fact that her parents were first cousins), is my mother's brother. He received (at least on paper) a 50% contribution to his X from this ancestor. Rather convenient considering that this is the family I have spent the most time researching since 1975 - and uncle may hold the key to open the door wider than my testing since Hannah "only" made a 25% contribution to my X (of course with recombination the actual percentage may vary dramatically away from the average - it could be 100% or it could be zero - but most likely the stated figure on the chart).

The great aspect of decodeme are the sophisticated features it offers. For example with one click I can compare my X with that of my uncle and see the regions of sharing (high, medium and low). I have not heard boo from 23andme as to their "plans for the X" but it does not appear to be a priority.

[Maria_W]

Cross validation...

Becasue its cross validation for DeCodeMe. I was given a 6% overall Asian ( result on autosomal and a 9% overall Asian result on x...I want to see what 23andme gives me...I know that DeCodeMe is more generous with their ethnic percentages..Want to see if its true, if both DeCodeme and 23andme are close in percentages than its probably correct...Since its only 400.00, why not...
For instance when you open the genome browser and you highlight Chromosome x down below it says my ancestry you have a graph. Yellow represents Asian. If you run the cursor across the whole length of the graph you will get different percentages for Asian. I get anywhere from 1.90% to 48.60% on my X chromosome...I guess they settled for 9% as a comprimise...

Maria

[tomcat]

Tom,
Duh, yes I did the DeCodeMe test..Will go look at my x results...But i don't know what to do with them..Guess I need to ask the people at Rootweb...

Be sure and let them know you have DXS10074,75,79 results at DNAF ... there ought to be a relationship, ancestry-wise, between your DXS matches and the ancestry of the corresponding SNP block.

[Kathleen Carrow]

Tom,
Duh, yes I did the DeCodeMe test..Will go look at my x results...But i don't know what to do with them..Guess I need to ask the people at Rootweb...

Thanks for reminding me about the x chromosome with Decodeme...Thinking about doing the 23andme test in May...

Maria

Maria
Don't the deCODE me folks help with comparisons? Don't they have a database?

Why would you do the 23andME test ..it is very similar isn't it? No more results to be had?

[Maria_W]

Duh...

Tom,
Duh, yes I did the DeCodeMe test..Will go look at my x results...But i don't know what to do with them..Guess I need to ask the people at Rootweb...

Thanks for reminding me about the x chromosome with Decodeme...Thinking about doing the 23andme test in May...

Maria

[tomcat]

...
Are there any more x markers out there to test?
...

If you did 23andMe or DeCode you got X SNP's to go along with your X STR's and so are way ahead of the rest of us. You might link-up with the Roostweb or DNAForum folk who are working with the X SNP's. Please report back!

[Maria_W]

Any comments....

Both my mother and father did the DNA Print test a 1 1/2 ago. Then my father passed away Sept 23, 2007 so it won't be possible to do any more testing on him.. In a casual conversation the other day my mother said no more dna for her. So won't be able to tell who's who's....

Just a reminder. My X results are:

Panel 1
DXS10011: 31.2-40
DXS10066: 13-14
DXS10067: 16-18
DXS10068: 18-23
DXS10069: 16-17
DXS10131: 9-9*

Panel 2
DXS10074: 13-15
DXS10075: 17-18
DXS10079: 17-21
DXS10132: 11-11*
DXS6807: 11-15
DXS7132: 13-15
DXS7423: 15-16
DXS8377: 44-46
DXS981: 14.3-15.3
HPRTB: 13-14

Tryed following X conversation on rootsweb and just got more confused
Are there any more x markers out there to test?
Any comments...

Maria

[tomcat]

I don't have a specific answer but, generally, the linked X STR's (DXS10074, 75, 79) OUGHT to definitively characterize the haploblock as defined by the scanner's SNP haploblocks...

This ought to work in reverse, that the STR-defined haploblock is a predictor of what one might find if SNP'd, but I can imagine situations in which such a conclusion would be wrong or unsupported by SNP evidence.

I think a pretty good indicator of that would be STR haploblock matches on DNAF that covered range of ancestries or ancestries that couldn't possible be genealogically correct. That might indicate that a variety of populations had converged on an identical STR block within differing SNP blocks.

[tomcat]

...
what I WOULD like to know is how have the SNP testings at 23andme and deCODEme helped put the XSTRs that we have tested here in a meaningful perspective?...

I don't have a specific answer but, generally, the linked X STR's (DXS10074, 75, 79) OUGHT to definitively characterize the haploblock as defined by the scanner's SNP haploblocks.

In example, say your SNP-defined haploblock that is co-extensive with DSX 10074, 75, 79, reads (on 23 or DeCode) as East Asian. Is that reading an ancient East Asian signal that might be present in Europeans, or is it actually, genealogically, East Asian, or is it genealogically Native American? The STR's embedded withing the SNP block (which are much younger than the SNP's) hold the PROMISE of answering that question.

[Kathleen Carrow]

There is a lot of work going on by genetic genealogists and people are posting their results for analysis at:

http://archiver.rootsweb.ancestry.co...GY-DNA/2009-01

and:

http://www.dna-forums.org

We really don't know what we are going to find until we start systematically looking.

We have an earlier much larger thread where we discussed the Szibor papers etc. before we tested our X markers..some of us here did it quite some time ago when they were first offered ..and posted them at DNA-FP

we cannot read the posts at dna-forums that is member only..
what I WOULD like to know is how have the SNP testings at 23andme and deCODEme helped put the XSTRs that we have tested here in a meaningful perspective?
What do you who have done that know that those of us who have done mtDNA FGS, complete or at least 21 marker autosomal, complete groups of X markers and 67 marker Y test plus SNPS for our male ancestors?
And is it worth the $$ ??

I have yet to read anything at the Rootsweb DNA Genealogy site ( Which I read daily) which indicates that anyone had a revelation after doing one of the full genome tests..

Just wondering

[DKF]

DKF,

Perhaps you could post here some of the analytical projects one can accomplish with X SNP's. There are options through the labs but what are the options among the genetic genealogical testing community?

Tom

There is a lot of work going on by genetic genealogists and people are posting their results for analysis at:

http://archiver.rootsweb.ancestry.co...GY-DNA/2009-01

and:

http://www.dna-forums.org

It might be a good idea to read some of the earlier posts to get a feel for the type of research being undertaken.

If it all seems very preliminary is is because most of us only "discovered" this area of research late in 2008 and so we are still taking baby steps. Clearly those of us who have tested with decodeme and 23andme are at an advantage since there is gold to be mined from the over half a million SNP markers.

The X STR markers from FTDNA can be linked to a paper that discusses the three markers noted in this thread - the results can be compared to the German samples and a very small number from Asia and Africa. At the moment it would probably be rare to find a "Irish pattern" or an "Ojibway pattern" or motif of allele values. People will need to be patient, dable a bit, compare notes, and decipher what it all may mean.

Alas, even with an exact match it could mean a close relationship within a genealogical time frame, or hark back to the "Out of Africa" event where a small subsample of African diversity squeezed out of the homeland and spread across the world. We really don't know what we are going to find until we start systematically looking.

[tomcat]

What I want to know is the following: If I order the X panel from FTDNA, in practical terms, what can I expect to learn? Also, once I receive the results, how do I decipher their meaning? ....

Well, as a male (XY) you know at the start that your X came from your mother and it is a recombined product of the two X's she had. And that the three linked X markers are in linkage disequilibrium, or not subject to recombination, so DXS10074, 75, 79 is one of the two sets of linked markers your mother had. If you test them and post them you might find matches to others that MIGHT give you more information about ancestry. It is pretty simple. But no guarantees. The more folks that test and post the more we all may learn.

[Kathleen Carrow]

What I want to know is the following: If I order the X panel from FTDNA, in practical terms, what can I expect to learn? Also, once I receive the results, how do I decipher their meaning? Does FTDNA provide any interpretation, would I have to enter my results some place else in order to get some feedback? I still do not fully comprehend which ancestors I am supposed to have inherited their chromosomes, genes or whatever you call them, from, following the X chromosome ancestry testing. I have seen the graphs, but they still look confusing to me and I really don't like to think hard, that is the reason I come here to get the input of smarter people like Tomcat, DKF etc. etc. To me this whole X chromosome thing looks and reads like a puzzle.

If you have already tested here at FTDNA then you can just test the 3 markers needed for the X haploblock that we have been discussing..
they are found in X Panel 2 and you can just order the three on them for $8.68each and some amount of money like $9.50..less than $30 for those 3..

FTDNA does not give any guidance on these markers and had stated that when they began to offer them..maybe someday..
BUT Thomas Krahn who is also at FTDNA and who owns DNA-Fingerprint has a website where you can sign up, put your markers in and "Run" them against other people's markers or block..
This website is interactive and if you match someone you can e-mail them right there..
here is the link to that:
http://www.dna-fingerprint.com/
any other questions you WILL have to ask the REAL "smart people" Like Tomcat and DKF..not me
like using SNPS and STRS together..that I do not understand conceptually