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New Results Haplogroup H Hvr1 2/Help!!

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  • vinnie
    replied
    Originally posted by GhostX
    Congratulations, Linda, that's better than I've been able to get, even after my FGS test!
    GhostX,

    This is a sincere response and not intended in anyway to disparage FGS. If you can't determine your subclade from the test, how useful is it for accomplishing what many of us are trying to do - uncover our historical roots within a given geographic and/or ethnic context? Aside from sheer "cost effectiveness" for those who have done little or no testing, why is this test better than a subclade test for those who have already spent money on HVR1 & 2? Subclades are cited in most of the published literature for determining geographic/ethnic distributions, and I'm hoping that more H people will test for it.

    Vinnie

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  • honeychild51943
    Guest replied
    Thanks Ghost
    putting in h7 in google and found some in Romania and other areas in theRussia /North Caucasus ect locals. Nothing definte but someplace new for me to explore. Thanks for the commet
    hugs
    Linda

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  • GhostX
    replied
    Originally posted by honeychild51943
    Hi Guys I got my results not too much info but did narrow down somewhat reads H7
    Congratulations, Linda, that's better than I've been able to get, even after my FGS test!
    Last edited by GhostX; 12 June 2008, 06:44 AM.

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  • honeychild51943
    Guest replied
    Got Subclade results H7 Where does this take me??

    Hi Guys I got my results not too much info but did narrow down somewhat reads H7

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  • honeychild51943
    Guest replied
    Thanks so much for all the help. I will post the new results when they come in.
    Linda

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  • vinnie
    replied
    Linda, thanks much for ordering the subclade test. Whatever the outcome, the results will help to better define Hg H for all of us...Vinnie

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  • GhostX
    replied
    Originally posted by honeychild51943
    Thanks again for all the help btw I did order the subclade test so maybe it will help with some location details.
    Linda
    You're very welcome, and I really hope the subclade test helps place you more specifically in the H tree. Good for you for ordering it.

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  • honeychild51943
    Guest replied
    Hi Ghostx
    Sorry I don't know which chromosome is trisomic. This is a new
    science for me. When my son was born 40 yrs ago I was told in genetic counciling that I had an extra chromosome, which I had a 50 50 chance of passing on to my offspring. The DNA science in 1967 was certainly in it's infancy. When my son's son was born with the extras also, the genetist
    attribitited it to our Native American ancestry. I would love to do the autosomal test but will have to save my money(sigh). Thanks again for all the help btw I did order the subclade test so maybe it will help with some location details.
    Linda

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  • GhostX
    replied
    You're very welcome, Linda. Do you know which of your chromosomes is trisomic? I think that's just fascinating.

    To answer Vinnie's question. I actually don't know if FTDNA will automatically give you a subclade assignment with the FGS test. As Cacio said though, it's an easy matter to figure out where on the tree you belong, from your list of FGS mutations. It does get a bit complicated in the H tree, because H includes the CRS, and you therefore have to move "backwards" through the tree in places, but it's explained in a fairly straightforward way here (just use whichever of your mutations are shown on the diagram, and ignore the rest for purposes of subclade determination):

    http://www.genebase.com/doc/mtdnaHaplogroup_H_Tree.pdf

    I actually don't mean to discourage people from getting the deep-clade test, as it does potentially reveal some useful information for some people. The FGS test provides useful information for all people though, if not immediately, then at least it will as new research is published. The deep-clade test is only useful for subclades that have been defined as of the present, so you may or may not get lucky with it. The FGS is just a far better value per dollar spent. If people are interested enough in mtDNA to get the deep-clade test, I'd strongly recommend just going for the full deal, as you'll probably just end up spending the extra money later anyway!

    I do completely agree with Vinnie that you have to be careful with the medical information that you can potentially get from a FGS test. I wouldn't reveal the coding-region portion of your FGS findings to anybody who you don't trust (your HVR1/HVR2 results are fine to share) until you are reasonably sure that you don't have any potentially harmful mutations.

    You can submit your FGS results to GenBank anonymously though, and I urge everybody to do this if you've gotten a FGS test, as we desperately need to expand the database. There are instructions for how to do that in a couple of recent posts somewhere on this forum.

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  • vinnie
    replied
    I also believe that people should think very hard about how they'll handle knowing any possible medical implications from the FGS. If one can take a pro-active, positive attitude to any negative findings, go for it. But I've seen little discussion about what I see as a serious issue to address before diving in. Not to mention that I'm waiting for the passage of comprehensive legislation that will protect testees from discrimination based on this test by insurance companies, employers, etc. I know some is in the works, but it hasn't been passed yet.

    In the mean time, there are literally thousands of mtDNA H people who could add much to our understanding of the haplogroup just by having the inexpensive subclade test done. I've got over 5000 low resolution Hg H "matches" and hundreds of high resolution "matches", but only a handful of confirmed H7's to work with for any attempt at a meaningful understanding of my results and the subclade in general.

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  • cacio
    replied
    I don't know if the ftdna people tell the clade themselves, but checking is really easy. One can look at the tree, for instance

    http://www.familytreedna.com/hclade2.html
    (towards the middle of the page)
    and check whether one has the required mutations.

    cacio

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  • vinnie
    replied
    But when someone gets FGS results, do those results include the actual subclade designation as does the subclade test, or does the testee have to interpret the results in order to determine the subclade? I'm asking because most of what I've seen written about the FGS seems to indicate that the results that testees are given then have to be interpreted by someone else in order to understand what the results mean. Not totally unlike what we all do with our initial dna tests, but at least those tell us our haplogroups. And while it is possible to get that * after one's results (that's what my y-DNA results are at the moment), that in itself is significant and is subject to change.
    Last edited by vinnie; 13 May 2008, 04:59 PM.

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  • honeychild51943
    Guest replied
    Hi Ghost thanks so much for your help! I intend to do the FGS as soon as I can afford it . I have an extra chronosome which might or might not help depending on If the mutation is just mine or shared by an ancestor. I have 6 toes and had an extra finger on left hand. Neither parent had the extras but 2 of my 3 children inherited it from me. I have 3 grandchildren who also have it. My son had 12 toes and 12 fingers as does his son who is a twin. Other twin does not. daughter had 12 toes and very tiny numb on left hand looks like small mole. She has 4 children a son and daughter inherited
    with 12 & 12. I will look forward to seeing if anything will come of that result.
    Been dong genealogy 40 yrs so have Long paper trail. Have native American and possible early 1770 african American lines that do not cross my Mt line.
    Extra toes ect are more common in American Indian families and Melungeon lines. But have not found link yet. Sorry getting off topic i will look into your suggestions and thanks so much for your help!

    Leave a comment:


  • GhostX
    replied
    Vinnie's suggestion to get the H deep-clade test isn't bad advice, but be prepared to potentially get nothing more than a disappointing asterisk next to your H haplogroup designation if you do that (H* means that the deep-clade test was of no help in classifying you to a subclade, though it does at least rule you out from being in any of the currently-described ones). That's what happened to me. The FGS test is far more useful, if you can afford it. I personally think that everybody should get a FGS test, but that's just me.

    As for the specifics of your mutations, Linda, all of your mutations except for 16262T are common. I have 263G, 315.1C, and 16519C myself. 16262T is found in about 6% of the people in the database I consulted (http://www.genpat.uu.se/mtDB/). Unfortunately none of those mutations is enough to tell you anything other than that you belong somewhere in the huge H haplogroup, so they won't really do much to help you narrow down your matches.

    Also, because haplogroup H is so common and widespread, I wouldn't read too much into any particular nationality being in your list of matches. Even a perfect match with HVR1+HVR2 results doesn't necessarily indicate a recent common ancestor, due to the very slow mutation rates of mtDNA. It's a place to start though!

    Again, you could learn a lot more from a FGS test (but only if you get lucky and match one of the relatively few people who have taken that test to date). At the very least, you'd be able to see if you have any mutations that are medically relevant to you.

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  • honeychild51943
    Guest replied
    Hi Vinnie thanks so much for your help.
    I have registered mitosearch & will join the other. I am surprised at the
    Germantic influnence, I have not found anyone from that area before. Mostly
    England Ireland and Scotland in Europe and Chickasaw,Cherokee and Choctaw in North American. However I am only back 5 generation on my Mit line to Louisa Hickman b 1806 in either Ky or IL. Thanks again for any help. If any one matches me please send me a note.
    Thanks so much Linda

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