New Results Haplogroup H Hvr1 2/Help!!

[honeychild51943]

Hi I got my long awaited results and can't make heads or tails of it!
HVR1 Haplogroup H
HVR1 differences 16261T

from CRS 16519C

HVR2 differences
from CRS 263G
309.1C
315.1C
Could someone explain some of this to me please??
Thanks so much Linda

[GhostX]

Hi I got my long awaited results and can't make heads or tails of it!
HVR1 Haplogroup H
HVR1 differences 16261T

from CRS 16519C

HVR2 differences
from CRS 263G
309.1C
315.1C
Could someone explain some of this to me please??
Thanks so much Linda

This basically means that you have a total of 5 mutations that differ from the Cambridge Reference Sequence (which is just the first person they happened to do a full sequence on, to form a reference standard). All your other nucleotides are an exact match to the CRS, so they are not listed as mutations. HVR1 and HVR2 are just different regions of non-coding mtDNA. The ".1C" suffixes mean that you have an inserted C base at nucleotide #309 and 315, respectively (an insertion is one type of mutation). The letters without a ".1" are substitution mutations (a different type of mutation), where one base got substituted for another.

Really the best thing you can do with your mutations to start, is enter them into the databases at www.mitosearch.com (you can transfer them over automatically from FTDNA) and www.smgf.org, and see if anybody else shares all of your mutations. You can also get lots of useful info at www.mitomap.org.

Let us know if any of that is unclear or didn't answer your question fully.

[vinnie]

Hi I got my long awaited results and can't make heads or tails of it!
HVR1 Haplogroup H
HVR1 differences 16261T

from CRS 16519C

HVR2 differences
from CRS 263G
309.1C
315.1C
Could someone explain some of this to me please??
Thanks so much Linda

Linda,

In my opinion, the best thing for you to do now would be to order the relatively inexpensive Hg H subclade test so you'll know which subgroup of H you belong to. Although I *think* that your HVR1 results are a bit uncommon, you could have literally hundreds of HVR1 matches, hundreds of HVR2 matches, and possibly hundreds of HVR1 & HVR2 high resolution matches that will have no practical significance for you if you don't know your subclade. The only other test that will do the same is the much more expensive and medically relevant full genomic sequence (FGS) test. Please also consider joining the Hg H project; the administrators may be able to tell you if your HVR1 results are representative of any particular subclade (subgroup) without having to have the test done.

Vinnie

[honeychild51943]

Hi Vinnie thanks so much for your help.
I have registered mitosearch & will join the other. I am surprised at the
Germantic influnence, I have not found anyone from that area before. Mostly
England Ireland and Scotland in Europe and Chickasaw,Cherokee and Choctaw in North American. However I am only back 5 generation on my Mit line to Louisa Hickman b 1806 in either Ky or IL. Thanks again for any help. If any one matches me please send me a note.
Thanks so much Linda

[GhostX]

Vinnie's suggestion to get the H deep-clade test isn't bad advice, but be prepared to potentially get nothing more than a disappointing asterisk next to your H haplogroup designation if you do that (H* means that the deep-clade test was of no help in classifying you to a subclade, though it does at least rule you out from being in any of the currently-described ones). That's what happened to me. The FGS test is far more useful, if you can afford it. I personally think that everybody should get a FGS test, but that's just me.

As for the specifics of your mutations, Linda, all of your mutations except for 16262T are common. I have 263G, 315.1C, and 16519C myself. 16262T is found in about 6% of the people in the database I consulted (http://www.genpat.uu.se/mtDB/). Unfortunately none of those mutations is enough to tell you anything other than that you belong somewhere in the huge H haplogroup, so they won't really do much to help you narrow down your matches.

Also, because haplogroup H is so common and widespread, I wouldn't read too much into any particular nationality being in your list of matches. Even a perfect match with HVR1+HVR2 results doesn't necessarily indicate a recent common ancestor, due to the very slow mutation rates of mtDNA. It's a place to start though!

Again, you could learn a lot more from a FGS test (but only if you get lucky and match one of the relatively few people who have taken that test to date). At the very least, you'd be able to see if you have any mutations that are medically relevant to you.

[honeychild51943]

Hi Ghost thanks so much for your help! I intend to do the FGS as soon as I can afford it . I have an extra chronosome which might or might not help depending on If the mutation is just mine or shared by an ancestor. I have 6 toes and had an extra finger on left hand. Neither parent had the extras but 2 of my 3 children inherited it from me. I have 3 grandchildren who also have it. My son had 12 toes and 12 fingers as does his son who is a twin. Other twin does not. daughter had 12 toes and very tiny numb on left hand looks like small mole. She has 4 children a son and daughter inherited
with 12 & 12. I will look forward to seeing if anything will come of that result.
Been dong genealogy 40 yrs so have Long paper trail. Have native American and possible early 1770 african American lines that do not cross my Mt line.
Extra toes ect are more common in American Indian families and Melungeon lines. But have not found link yet. Sorry getting off topic i will look into your suggestions and thanks so much for your help!

[vinnie]

But when someone gets FGS results, do those results include the actual subclade designation as does the subclade test, or does the testee have to interpret the results in order to determine the subclade? I'm asking because most of what I've seen written about the FGS seems to indicate that the results that testees are given then have to be interpreted by someone else in order to understand what the results mean. Not totally unlike what we all do with our initial dna tests, but at least those tell us our haplogroups. And while it is possible to get that * after one's results (that's what my y-DNA results are at the moment), that in itself is significant and is subject to change.

[cacio]

I don't know if the ftdna people tell the clade themselves, but checking is really easy. One can look at the tree, for instance

http://www.familytreedna.com/hclade2.html

(towards the middle of the page)
and check whether one has the required mutations.

cacio

[vinnie]

I also believe that people should think very hard about how they'll handle knowing any possible medical implications from the FGS. If one can take a pro-active, positive attitude to any negative findings, go for it. But I've seen little discussion about what I see as a serious issue to address before diving in. Not to mention that I'm waiting for the passage of comprehensive legislation that will protect testees from discrimination based on this test by insurance companies, employers, etc. I know some is in the works, but it hasn't been passed yet.

In the mean time, there are literally thousands of mtDNA H people who could add much to our understanding of the haplogroup just by having the inexpensive subclade test done. I've got over 5000 low resolution Hg H "matches" and hundreds of high resolution "matches", but only a handful of confirmed H7's to work with for any attempt at a meaningful understanding of my results and the subclade in general.

[GhostX]

You're very welcome, Linda. Do you know which of your chromosomes is trisomic? I think that's just fascinating.

To answer Vinnie's question. I actually don't know if FTDNA will automatically give you a subclade assignment with the FGS test. As Cacio said though, it's an easy matter to figure out where on the tree you belong, from your list of FGS mutations. It does get a bit complicated in the H tree, because H includes the CRS, and you therefore have to move "backwards" through the tree in places, but it's explained in a fairly straightforward way here (just use whichever of your mutations are shown on the diagram, and ignore the rest for purposes of subclade determination):

http://www.genebase.com/doc/mtdnaHaplogroup_H_Tree.pdf

I actually don't mean to discourage people from getting the deep-clade test, as it does potentially reveal some useful information for some people. The FGS test provides useful information for all people though, if not immediately, then at least it will as new research is published. The deep-clade test is only useful for subclades that have been defined as of the present, so you may or may not get lucky with it. The FGS is just a far better value per dollar spent. If people are interested enough in mtDNA to get the deep-clade test, I'd strongly recommend just going for the full deal, as you'll probably just end up spending the extra money later anyway!

I do completely agree with Vinnie that you have to be careful with the medical information that you can potentially get from a FGS test. I wouldn't reveal the coding-region portion of your FGS findings to anybody who you don't trust (your HVR1/HVR2 results are fine to share) until you are reasonably sure that you don't have any potentially harmful mutations.

You can submit your FGS results to GenBank anonymously though, and I urge everybody to do this if you've gotten a FGS test, as we desperately need to expand the database. There are instructions for how to do that in a couple of recent posts somewhere on this forum.

[honeychild51943]

Hi Ghostx
Sorry I don't know which chromosome is trisomic. This is a new
science for me. When my son was born 40 yrs ago I was told in genetic counciling that I had an extra chromosome, which I had a 50 50 chance of passing on to my offspring. The DNA science in 1967 was certainly in it's infancy. When my son's son was born with the extras also, the genetist
attribitited it to our Native American ancestry. I would love to do the autosomal test but will have to save my money(sigh). Thanks again for all the help btw I did order the subclade test so maybe it will help with some location details.
Linda

[GhostX]

Thanks again for all the help btw I did order the subclade test so maybe it will help with some location details.
Linda

You're very welcome, and I really hope the subclade test helps place you more specifically in the H tree. Good for you for ordering it.

[vinnie]

Linda, thanks much for ordering the subclade test. Whatever the outcome, the results will help to better define Hg H for all of us...Vinnie

[honeychild51943]

Thanks so much for all the help. I will post the new results when they come in.
Linda

[honeychild51943]

Got Subclade results H7 Where does this take me??

Hi Guys I got my results not too much info but did narrow down somewhat reads H7