Announcement

Collapse
No announcement yet.

Help with understanding some terms

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Help with understanding some terms

    Have been trying to find some definitions on the following terms:

    HVR1
    HVR2
    CR

    Also, What is DYS# 607 and what would an Alleles of 15 for that DYS# indicate? I am 1 marker different from two other participants in my project out of 37 markers and the difference is in DYS# 607.

    Would appreciate your help.

    Thanks

  • #2
    rond:

    HVR1= hypervariable region 1 (similar for 2)
    CRS=common reference sequence (if that's what you were asking)

    mtDNA is composed by around 16,600 bases (A,C,G, or T). HVR1 are the last 600 bases or so (ie after position 16,000), HVR2 are the first ones (ie 1 to 600 or so). Actually, first or last is a little bit incorrect because the mtdna is a loop. They are called hypervariable because mutations are more frequent there than in the rest of the DNA. As such, they give more information, and that's why they are the first ones to be tested. The reason for this is partly that they are junk, they do not code for anything. Therefore, mutations can accumulate. The rest of the mtdna is called coding region. In the coding region, there are actual genes.

    Most of the mtdna is the same for all people, there are only up to 20-30 different bases, at most. So, to represent mtdna, scientist use a reference sequence (which happens to be the first mtdna that was sequenced), and only write the bases that were different from CRS. CRS happens to be in haplogroup H2, and that is why people in H have usually few differences from CRS.

    cacio

    Comment


    • #3
      Originally posted by rond
      Have been trying to find some definitions on the following terms:

      HVR1
      HVR2
      CR

      ........
      In mtDNA "CR" indicates "Coding Region" which is only scanned for mutations with an FGS (Full Genome Scan). The definitions of mtDNA Haplogroups are based on mutations across the full Genome, so Haplogroup designations based on HVR1 (Hyper Variable Region, some papers use HVS and some "control region") are estimates. HVR1 and HVR2 are the opposite ends of the Mitochondria double Helix that are joined together to form the loop.
      Last edited by fmoakes; 2 September 2007, 11:06 AM.

      Comment


      • #4
        Thanks for the help with the terms.

        Is there any information on DYS #607? What does it mean?

        RonD

        Comment

        Working...
        X