Dave:
I am always skeptical of unsubstantiated claims. Why didn't they say exactly what they tested? Then one can evaluate their claim. As we discussed with Andrew, "proof by intimidation" is not very convincing.
I suspect 16223 is not a necessary condition, I think we discussed this with vraatyah in a previous post. I know there are of M's without it (eg Andrew's wife, if I recall). And vraatyah pointed out that in the case of mtDNA one must look at the entire motif. The lack of one indicative mutation cannot be taken in isolation. Backmutations do happen. So if the sequence looks like something, except for one locus, then may be it is what it looks like.
In your case, where would M* come from? Europe has M1 (which you are not), may be a tiny M5 (but you are not gypsy). M* is found is south-east Asia, but you don't seem to have any connection there. But America has C.
Regarding M1, they don't have samples because M1 has its largest frequencies in Ethiopia and North Africa (from where hardly anybody has tested), and from there it went to Spain and Italy, but in small numbers. Plus, Spain and Italy have not been tested in decent numbers either. There is little or no M1 in the UK.
I guess the problem will be solved completely only if you sequence the entire mtdna (which is now possible for $350...)
cacio
I am always skeptical of unsubstantiated claims. Why didn't they say exactly what they tested? Then one can evaluate their claim. As we discussed with Andrew, "proof by intimidation" is not very convincing.
I suspect 16223 is not a necessary condition, I think we discussed this with vraatyah in a previous post. I know there are of M's without it (eg Andrew's wife, if I recall). And vraatyah pointed out that in the case of mtDNA one must look at the entire motif. The lack of one indicative mutation cannot be taken in isolation. Backmutations do happen. So if the sequence looks like something, except for one locus, then may be it is what it looks like.
In your case, where would M* come from? Europe has M1 (which you are not), may be a tiny M5 (but you are not gypsy). M* is found is south-east Asia, but you don't seem to have any connection there. But America has C.
Regarding M1, they don't have samples because M1 has its largest frequencies in Ethiopia and North Africa (from where hardly anybody has tested), and from there it went to Spain and Italy, but in small numbers. Plus, Spain and Italy have not been tested in decent numbers either. There is little or no M1 in the UK.
I guess the problem will be solved completely only if you sequence the entire mtdna (which is now possible for $350...)
cacio
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