Thoughts About 16519??

[T. Allen]

im Haplogroup H28a2 and i have HVR1-mutation 16519C

[tomcat]

Thanks for that! It helps. Just when I think I have a handle on learning this "stuff" something new comes along and twists the road a bit and "... that's a good thing." Thanks again!

Please consider adding your FGS to GenBank. There is a thread on that topic running on the Mitosearch.org section of this forum.

[railwayop]

When FTDNA seq'd your mtDNA they found two versions (nothing to worry about we all have multiple versions of mtDNA). So, at position 8851, you have a T (thymine) and a G (guanine) version (and possibly others undisclosed).

The 16519C is an example of typical notation, with just a single letter, such as C (cytosine) or A (adenine).

Thanks for that! It helps. Just when I think I have a handle on learning this "stuff" something new comes along and twists the road a bit and "... that's a good thing." Thanks again!

[tomcat]

When FTDNA seq'd your mtDNA they found two versions (nothing to worry about we all have multiple versions of mtDNA). So, at position 8851, you have a T (thymine) and a G (guanine) version (and possibly others undisclosed).

The 16519C is an example of typical notation, with just a single letter, such as C (cytosine) or A (adenine).

[railwayop]

16519c

Could some one possibly explain the following:

"... mutations are normally listed as something similar to '16519C.' Your heterplasmy mutation is listed as 8851 T/G ..." (I received my FGS sometime ago and am trying to learn my way through all that now.)

Does this means 16519C is 8851 T/G? And what does the mutation 8851 T/G mean? (Funny, I was searching online and found a site that shows the baboon having this too (and a few other primates - actually quite interesting!))

Thanks,
Robbie

[GregKiroKHR1bL1]

No, I think Dr. Fan told our class the best answer for these things when I took his ecology class. He said that these are thoughts of ecologist, but none of them would consider their ideas law.

When I began to search for the specifics and then research the specifics, I found out how little I knew. And then I began to write about my thoughts which of course I would not consider law.

I always wondered how it would be if I lived with the Saber Tooth Tiger, or what life would be like in the snow filled mountains.

this is way to big for my litle brain..
Are they saying . if you came from hunter gathers there might be a reason you need to remain very active and continue to eat lean and wild coarse and whole .. it's in your genes..?
if you are adapted to cold climates youmight need higher fat foods, high energy foods and you might have to stay in cold climates for optimum health .. because it is in your genes? if that is what it is saying , then I will agree.. both lifestyles would burn off extra un needed calories if you are being true to that cellular predetermined lifestyle. thus your longevity would go up. I think .

[purple flowers]

I am not sure. After all, I am kicking around some ideas . . . I wrote some informal papers on type one and type two muscles. The idea of having to escape wild animals like the saber tooth tiger or adapting to new climate conditions have fascinated me in the past. Muscle and brain development is very important to the mtDNA. So, environmental conditions dictate survival. If one does not have the needed survival skills, then the individual will not reproduce, right or wrong has nothing to do with it. Mitomap has a good write up on adaptive ancient mtDNA. Also, the Ruiz-Pesini et al. 2004:226 article mentions it too. The research in the literature might suggest that some alleles are more adaptive in humans than other alleles in humans. So, how is human mtDNA different from plant mtDNA and such?

this is way to big for my litle brain..
Are they saying . if you came from hunter gathers there might be a reason you need to remain very active and continue to eat lean and wild coarse and whole .. it's in your genes..?
if you are adapted to cold climates youmight need higher fat foods, high energy foods and you might have to stay in cold climates for optimum health .. because it is in your genes? if that is what it is saying , then I will agree.. both lifestyles would burn off extra un needed calories if you are being true to that cellular predetermined lifestyle. thus your longevity would go up. I think .

[purple flowers]

I am an H 16519C. I live in Florida. My great great great great grandmother was from Virginia/North Carolina. Her fathers surname originated from Cornwall. I didn't know if her mom was also English or Native American. Since the test came back as H, I now know the mother was most likely also from Cornwall, England.
Is H 16519C found in Cornwall, England? Is Cornwall considered a 'trade spot'/'trade route'? I read that Phoenicians liked the tin from that area. Maybe there is Phoenician mixed in in my line?
My mom has very wild curly dark hair & eyes. Someday I'll like to get the 'autosomal' test done. Maybe there is some American Indian there somewhere. Or gypsy? I read the thread about English gypsies. She thinks I'm part Mongolian or Hun on my fathers side.

hi rainbow again I have been trying to figure a few things for myself.. if we came from the rising of the sun like my gggg grandfather said.. then I have been trying to figure out by who is in known pheoncians areas and from places slaves went back from here .. so which dna most likely got here really early .. I do not know who is claiming to be native and are being told they are not yet .. .. but I doubt they get many U5b2 with inca bones to back out of their claims any time soon ..

so just wait on your H and lets see ok... as H are amoung some of the most likely to be early travelers with R and I 's .. so lets wait and see.

[jan]

Oh, ok! Got it.

[cacio]

jan:

I meant 16223, not 16233. 16223 is the ancestral state because it is found in all haplogroups except the R descendants.

cacio

[jan]

GregKiroKH2:

the hotspots (16519, 309.1 and 315.1, deletions around 522) are not related to each other, they can happen in any combination in any haplogroup.

And I had never heard of 16223 as a neanderthal marker. 16233 is the ancestral state. It is in the Western Eurasian lineages that 16233 mutated.



cacio

Could you explain what you mean here, because I have seen the 16233 mutation in L2b lineages as well.

[GregKiroKH2]

I liked reading about the Saber Tooth Tiger so much when I was younger. I brought a giant poster of a cartoon one. Some types of bacteria and the Saber Tooth Tiger interact with humans harshly. Maybe, they did not influence 16519 mutation, but it is interesting to think what those tiger teeth could do which could be the same result as bacteria entering a cell.

When ROS production exceeds the capacity of detoxification and repair pathways, oxidative damage to protein, DNA, and phospholipid occurs, disrupting mitochondrial oxidative phosphorylation and leading to cell damage and death. . . . Here we have investigated how a series of exogenous ubiquinone analogs interact with oxidative phosphorylation and with ROS metabolism.
http://www.jbc.org/cgi/content/full/280/22/21295

please understand i am mixed dominant [au contraire]
thats why i am like i am

that said how did we grow the muscles to go fast did we lose enough humans to survive sabers were we bunnies mass poducing saying we need more kids so we can feed the saber long enough to get the mucsles to change so we could beat him? hmm.

bacteria sure they have something you might call instinct . why because they remember the way to infect. they dont get inside you and say what are we doing here? zing they zip to the best place to kill you

now compare that to the saber did we stop the saber meals when evolution gave us muscles faster then the bacteria knew to find the right spot.
this is like those treees with the seeds that you canslpit and put on your nose. how long did the tree drop seeds straight down until it knew it needed wings? questions ,questions ,questions ,questions ,?


we all need to remember that this mtdna is women who could of been slaves or daughter sold to slavery or as wives to travelers. hookers following the gold rushes or trade routes looking for merchants with cash. wives of soldiers.women stolen in raids.
again i think the best approach is small area studies i think these will find the clusters of 519 take a look at the frosinone study .one of mine seems 519 is a strong number there this area is alot of small farming villages on the sides of hills and vast intermarring in these towns so alot of the same mtdna lines with the same basic numbers

[Jim Denning]

Kimura argued that the level of genetic variation present in natural populations could not be maintained by selection. I do not know what he would say about 16519 thou. Still, under this model, polymorphism is transient and stochastic, and differences in allele frequency among populations need not be adaptive. And so does 16519. By the way, those who could not run away and steal food from the saber tooth tiger might have been eaten. They needed the muscles to run. When this behavior entered into the tribal domains, running away was not as important as bartering a trade to escape tribal justice. The saber tooth tiger had the right idea, but they did not survival their hard line approach. And 16519 just does not seem to fit into some populations.

So, do bacteria have a memory?

please understand i am mixed dominant [au contraire]
thats why i am like i am

that said how did we grow the muscles to go fast did we lose enough humans to survive sabers were we bunnies mass poducing saying we need more kids so we can feed the saber long enough to get the mucsles to change so we could beat him? hmm.

bacteria sure they have something you might call instinct . why because they remember the way to infect. they dont get inside you and say what are we doing here? zing they zip to the best place to kill you

now compare that to the saber did we stop the saber meals when evolution gave us muscles faster then the bacteria knew to find the right spot.
this is like those treees with the seeds that you canslpit and put on your nose. how long did the tree drop seeds straight down until it knew it needed wings? questions ,questions ,questions ,questions ,?


we all need to remember that this mtdna is women who could of been slaves or daughter sold to slavery or as wives to travelers. hookers following the gold rushes or trade routes looking for merchants with cash. wives of soldiers.women stolen in raids.
again i think the best approach is small area studies i think these will find the clusters of 519 take a look at the frosinone study .one of mine seems 519 is a strong number there this area is alot of small farming villages on the sides of hills and vast intermarring in these towns so alot of the same mtdna lines with the same basic numbers

[GregKiroKH2]

Kimura argued that the level of genetic variation present in natural populations could not be maintained by selection. I do not know what he would say about 16519 thou. Still, under this model, polymorphism is transient and stochastic, and differences in allele frequency among populations need not be adaptive. And so does 16519. By the way, those who could not run away and steal food from the saber tooth tiger might have been eaten. They needed the muscles to run. When this behavior entered into the tribal domains, running away was not as important as bartering a trade to escape tribal justice. The saber tooth tiger had the right idea, but they did not survival their hard line approach. And 16519 just does not seem to fit into some populations.

So, do bacteria have a memory?

i imagine we never were in the race until we developed things like clovis and team hunting saber tooth vs one human is a loser but 15 humans with clovis points is a different matter.i would guess teams & weapons came before muscle changes in development had time to form

[GregKiroKH2]

Stochastic vs. Adaptive Polymorphism

Trade routes seem to suggest more of a stochastic mutation mechanism for 16519 than the adaptive polymorphism mechanism climate type change everyone talks about . . .

In fact, codon bias is more extreme in highly-expressed genes than in rarely-transcribed genes (where it is weak to non-existent). In addition, codon bias (at least in humans) in more extreme in 3rd position GC-rich genes than in AT-rich genes. Finally, the pattern of codon bias is species-specific
selection-mutation-drift hypothesis. Here, selection for optimal codons is balanced by the effects of mutation and drift allowing persistence of non-optimal codons
If recombination is sufficiently rare in this region, these hitchhiking alleles can actually become fixed along with the advantageous allele at the selected locus.
Dispersed repeated sequences are spread throughout the genome, and represent transposable elements (SINEs and LINEs)
variable number of tandem repeat (VNTR) loci as they typically show high levels of variation in repeat number among chromatid copies. VNTR loci (particularly SSRs) show extermely high mutation rates
http://bioweb.wku.edu/faculty/McElro.../524lects5.htm

i THINK OF HRV NUMBERS AS ROADS
some female started her trip on the 519 interstate and took several roads to get to where we are now. on the chart is her road trip map.
our job is to see where 519 was when that person was there think of the staircases in harry potter that move these would be interdemensional since my 519 might be in ireland my wifes might be in italy