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Whe Do Mutations Occur

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  • Guest's Avatar
    Guest replied
    Answers to your questions

    "When do mutations occur? At conception? During embryonic development? During normal lifespan?"

    Mutations occur all the time, and almost all the time they are fixed by the body's normal repair mechanism. They can happen at conception (although that is a brief instant in time and not likely). They can happen during embryonic development, although only mutations that occurred to the Y chromosome in the sperm cells of the embryo would be passed on to the next generation. They can happen during normal lifespan, again with the understanding that while they happen to all cells, it only matters if they happen to the sperm cells and can be passed on.

    "Could two brothers have a haplotype mismatch, due to one (firstborn) inheriting a non-mutant Y-chromosome and the second brother inheriting a mutated Y-chromosome!]"

    The father only has ONE Y chromosome in all of his cells. There is no mutant Y and normal Y. It could be that one of the Y chromosomes in the father's sperm cell became mutated. The more likely answer is that the two brothers have different fathers.

    "When a new mutation occurs in generation "x", do all of the generation x person's chromosomes exhibit the change or just the one in the spermcell that is passed-down?"

    Only the cell that had the mutation and the cells that were produced from that cell. And it has to be a sperm cell where the Y mutation took place or it couldn't be inherited.

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  • wolong
    started a topic Whe Do Mutations Occur

    Whe Do Mutations Occur

    When do mutations occur? At conception? During embryonic development? During normal lifespan? Could two brothers have a haplotype mismatch, due to one (firstborn) inheriting a non-mutant Y-chromosome and the second brother inheriting a mutated Y-chromosome!] When a new mutation occurs in generation "x", do all of the generation x person's chromosomes exhibit the change or just the one in the spermcell that is passed-down?
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