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mtDNA 5 Extra Mutations???

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  • DeniseNiot
    replied
    EXTRA MUTATIONS

    I have:
    315.1C
    T8337C
    G8860A
    T11299C
    C16189T
    C16519T

    What is the James Lick thing do?

    http://dna.jameslick.com/mthap/[/QUOTE]
    Last edited by DeniseNiot; 10 March 2016, 08:04 PM. Reason: error

    Leave a comment:


  • Noplcelikegenome
    replied
    Clarification and Thanks

    Originally posted by dna View Post
    It is difficult to write a response to you without knowing what you had ordered, and what you wanted to achieve.

    From you had written so far (H5a1 - meaning you had the FMS test), your matriline (mother of your mother etc.) has European heritage. mtDNA test is examining only that particular line of relationship. Very much so like Y chromosome testing (let's say Y-DNA37 or Y-DNA67 at FTDNA) is only, and only looking at a patriline (father of father of etc.).

    Most likely you did not test to learn about any specific mutation, so normally you would not have any need to look at them. Genetic genealogy works by comparing results (and a computer does that for you). Did you check your mtDNA matches?

    And to broaden the picture:
    • FTDNA offers of choice of DNA tests:
      • autosomal (Family Finder)
      • FMS (mtDNA, tracing matrilineal relationships only), this the one you took
      • Y DNA STRs & SNPs (tracing patrilineal relationships only)
      • additional tests e.g. X STR markers.
    • Autosomal DNA results are limited to finding recent relationships only.
    • mtDNA and Y DNA results allow one to go much, much deeper in time, but usually one cannot even estimate the degree/level of relationship (e.g. the 3rd cousin might be indistinguishable from the 6th cousin using mtDNA or Y chromosome testing only).


    There is not a single type of a DNA test that has all the answers. However, like in any other genealogical research, all**** the potential avenues should be explored. And as in any genealogical research, funding is often a limiting factor...

    W. (Mr.)

    **** Not every DNA test type makes sense for everybody. The best known exception: Y DNA tests cannot be done by women.
    Thank you to all who offered insight on my frustrations. To answer the test questions I had the full mtDNA test run on myself and the Y37 for my brother. These appeared to offer the most information for the amount I could afford at the time. I was very unsure of how to start so I consulted my niece who is a biomed student.
    Anyway, I did look at all the links on the dashboard, but I am not sure what to do with them. I had 56 "exact matches".
    My goal is to map our family tree, since we have many missing pieces and more questions than answers. Based on the best information that I could understand through web research, I took a shot and started with FMA.

    Leave a comment:


  • hazel_ion
    replied
    I am L3e2a ~ did the full seq.

    HVR1 DIFFERENCES FROM rCRS
    16093C
    16223T
    16257T
    16290A
    16320T
    16519C

    HVR2 DIFFERENCES FROM rCRS
    73G
    146C
    150T
    152C
    195C
    263G
    309.1C
    315.1C
    522-
    523-

    CODING REGION DIFFERENCES FROM rCRS
    750G
    1438G
    2352C
    2706G
    4769G
    4823C
    7028T
    8701G
    8860G
    9196A
    9540C
    10398G
    10819G
    10873C
    11719A
    12705T
    13105G
    14212C
    14766T
    14869A
    14905A
    15301A
    15326G


    in my RSRV I also have!


    Extra Mutations

    309.1C

    315.1C

    G9196A

    T16093C

    C16257T

    C16290a


    Missing Mutations

    C146T

    C152T

    Leave a comment:


  • LadyAlaise
    replied
    So I have been emailing back and forth with the U3 project admin and she said that most of my extra mutations are fairly common; the one she was really interested in was a mutation in my Coding region (marker 9615 I think) she said that it is Unique in U3a1c as in NO ONE ELSE thus tested has it!!! (Um...WOW ) She said it will be helpful in the future, finding others who have it, as they would be much more closely related to me within U3a1c...

    Leave a comment:


  • J. R. L.
    replied
    My results were never in the email, I found out only when accessing the site, where it seems every result is incomplete unless you pay to upgrade. My mother thinks it is all a scam. I was so hoping to understand this so I could put together our family history.
    Any insight is appreciated. Thank you.[/QUOTE]

    1. My daughter and I have never gotten any info in an email. We check FTdna a few times a week to see when results are expected.
    2. Mtdna just gives a general background to see where your mother's mother's line came from a few thousand years ago. My daughter did hers to see if she was Jewish. The last woman she knew of was from Prussia. The Mtdna was consistent with a woman from Northern Europe.
    I may do my Mtdna next year, just out of curiosity to see if my ancestor is European or Native American. If she is European can I find out if she is from the British Isles? I don't know if the answers will be that specific.
    3. To find 2nd cousins to 5th cousins, do Family Finder. It usually costs $99. Sometimes there is a coupon for $10 or $20 off the regular price.
    Yesterday my daughter found a 4th cousin 1 generation removed and his daughter from FF's dna matches. It only worked because she and the other daughter had excellent family trees going back to 1800. Usually we find 2nd-3rd cousins.
    I found the granddaughter of my first cousin whom I used to visit when my parents went out-of-town 80 years ago. I am 90.My dau does my typing.
    I hope you do as much as you can on your family tree, and then do the Family Finder. When you know the children of your great-great grandparents and who they each married, it's easier to make matches based on dna.

    Good luck,
    Bob

    Leave a comment:


  • dna
    replied
    Originally posted by Noplcelikegenome View Post
    This is my first post, and I am so confused. Nevertheless, while searching for some understanding, I noticed that I, too have some of these same mutations. I will offer my newly discovered results.

    I am a H5a1 Haplo group, with 16340C 16519C, 309.1C, 309.2C, 315.1C, 456T, 522-,523-.

    I do not know what FASTA is or James Lick. I am starting to get discouraged.

    My results were never in the email, I found out only when accessing the site, where it seems every result is incomplete unless you pay to upgrade. My mother thinks it is all a scam. I was so hoping to understand this so I could put together our family history.
    Any insight is appreciated. Thank you.
    It is difficult to write a response to you without knowing what you had ordered, and what you wanted to achieve.

    From you had written so far (H5a1 - meaning you had the FMS test), your matriline (mother of your mother etc.) has European heritage. mtDNA test is examining only that particular line of relationship. Very much so like Y chromosome testing (let's say Y-DNA37 or Y-DNA67 at FTDNA) is only, and only looking at a patriline (father of father of etc.).

    Most likely you did not test to learn about any specific mutation, so normally you would not have any need to look at them. Genetic genealogy works by comparing results (and a computer does that for you). Did you check your mtDNA matches?

    And to broaden the picture:
    • FTDNA offers of choice of DNA tests:
      • autosomal (Family Finder)
      • FMS (mtDNA, tracing matrilineal relationships only), this the one you took
      • Y DNA STRs & SNPs (tracing patrilineal relationships only)
      • additional tests e.g. X STR markers.
    • Autosomal DNA results are limited to finding recent relationships only.
    • mtDNA and Y DNA results allow one to go much, much deeper in time, but usually one cannot even estimate the degree/level of relationship (e.g. the 3rd cousin might be indistinguishable from the 6th cousin using mtDNA or Y chromosome testing only).


    There is not a single type of a DNA test that has all the answers. However, like in any other genealogical research, all**** the potential avenues should be explored. And as in any genealogical research, funding is often a limiting factor...

    W. (Mr.)

    **** Not every DNA test type makes sense for everybody. The best known exception: Y DNA tests cannot be done by women.
    Last edited by dna; 19 April 2015, 06:52 PM.

    Leave a comment:


  • Noplcelikegenome
    replied
    Me, too!

    This is my first post, and I am so confused. Nevertheless, while searching for some understanding, I noticed that I, too have some of these same mutations. I will offer my newly discovered results.

    I am a H5a1 Haplo group, with 16340C 16519C, 309.1C, 309.2C, 315.1C, 456T, 522-,523-.

    I do not know what FASTA is or James Lick. I am starting to get discouraged.

    My results were never in the email, I found out only when accessing the site, where it seems every result is incomplete unless you pay to upgrade. My mother thinks it is all a scam. I was so hoping to understand this so I could put together our family history.
    Any insight is appreciated. Thank you.

    Leave a comment:


  • Littlest bit
    replied
    I am J1c3i and FTDNA says I have 8 extra mutations:
    309.1C
    315.1C
    522.1A
    522.2C
    T5442C - defining J1c3i
    C12858T
    A15758G - defining J1c3i
    C16519T

    However, when I run my Fasta file through the James Lick mtdna analysis tool, it's shows 2 are defining mutations for J1c3i and it only lists these as my extra mutations: (309.1C) (315.1C) 12858T. 16519 is a goofy mutation, so if anyone else gets it as an extra, here ya go:
    http://www.jogg.info/12/SatiableCuriosityHTML.htm


    FTDNA only lists me as J1c3, but J1c3i was added to the Phylotree in Build 15, Sept 2012. I assume FTDNA is behind on updating to the current Phylotree so you might want to download the Fasta file (if that is still possible) and running through the James Lick tool. Some of your extras could be defining mutations for a new mtdna:
    http://dna.jameslick.com/mthap/

    Leave a comment:


  • Zagard
    replied
    I have 6 extra mutaions for T2b4 and no exact match and no with genetic distance of 1. I have 20 matches with a distance of 2 and 41 with a distance of 3.

    Leave a comment:


  • PDHOTLEN
    replied
    I have 8 extra mutations for my U5b2b2. And after several years, still no exact match! I have two matches with one difference.

    Leave a comment:


  • LadyAlaise
    started a topic mtDNA 5 Extra Mutations???

    mtDNA 5 Extra Mutations???

    Ok, so I finally got my mtDNA Full sequence in; I am U3a1c...with 5 extra mutations...How could I have extra mutations and 5 of them??? (what does that mean??) and could this be why I have NO EXACT matches under HVR1, HVR2 And Coding Region (all together)? The nearest I have are two; one is a 2step match and one is a 3step match (I think I understand what that means?)
    Here are my extra mutations:
    A214R
    315.1C
    522.1A
    522.2C
    T9615C
    any help explaining this would be awesome!
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