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  • mtDNA 5 Extra Mutations???

    Ok, so I finally got my mtDNA Full sequence in; I am U3a1c...with 5 extra mutations...How could I have extra mutations and 5 of them??? (what does that mean??) and could this be why I have NO EXACT matches under HVR1, HVR2 And Coding Region (all together)? The nearest I have are two; one is a 2step match and one is a 3step match (I think I understand what that means?)
    Here are my extra mutations:
    A214R
    315.1C
    522.1A
    522.2C
    T9615C
    any help explaining this would be awesome!

  • #2
    I have 8 extra mutations for my U5b2b2. And after several years, still no exact match! I have two matches with one difference.

    Comment


    • #3
      I have 6 extra mutaions for T2b4 and no exact match and no with genetic distance of 1. I have 20 matches with a distance of 2 and 41 with a distance of 3.

      Comment


      • #4
        I am J1c3i and FTDNA says I have 8 extra mutations:
        309.1C
        315.1C
        522.1A
        522.2C
        T5442C - defining J1c3i
        C12858T
        A15758G - defining J1c3i
        C16519T

        However, when I run my Fasta file through the James Lick mtdna analysis tool, it's shows 2 are defining mutations for J1c3i and it only lists these as my extra mutations: (309.1C) (315.1C) 12858T. 16519 is a goofy mutation, so if anyone else gets it as an extra, here ya go:
        http://www.jogg.info/12/SatiableCuriosityHTML.htm


        FTDNA only lists me as J1c3, but J1c3i was added to the Phylotree in Build 15, Sept 2012. I assume FTDNA is behind on updating to the current Phylotree so you might want to download the Fasta file (if that is still possible) and running through the James Lick tool. Some of your extras could be defining mutations for a new mtdna:
        http://dna.jameslick.com/mthap/

        Comment


        • #5
          Me, too!

          This is my first post, and I am so confused. Nevertheless, while searching for some understanding, I noticed that I, too have some of these same mutations. I will offer my newly discovered results.

          I am a H5a1 Haplo group, with 16340C 16519C, 309.1C, 309.2C, 315.1C, 456T, 522-,523-.

          I do not know what FASTA is or James Lick. I am starting to get discouraged.

          My results were never in the email, I found out only when accessing the site, where it seems every result is incomplete unless you pay to upgrade. My mother thinks it is all a scam. I was so hoping to understand this so I could put together our family history.
          Any insight is appreciated. Thank you.

          Comment


          • #6
            Originally posted by Noplcelikegenome View Post
            This is my first post, and I am so confused. Nevertheless, while searching for some understanding, I noticed that I, too have some of these same mutations. I will offer my newly discovered results.

            I am a H5a1 Haplo group, with 16340C 16519C, 309.1C, 309.2C, 315.1C, 456T, 522-,523-.

            I do not know what FASTA is or James Lick. I am starting to get discouraged.

            My results were never in the email, I found out only when accessing the site, where it seems every result is incomplete unless you pay to upgrade. My mother thinks it is all a scam. I was so hoping to understand this so I could put together our family history.
            Any insight is appreciated. Thank you.
            It is difficult to write a response to you without knowing what you had ordered, and what you wanted to achieve.

            From you had written so far (H5a1 - meaning you had the FMS test), your matriline (mother of your mother etc.) has European heritage. mtDNA test is examining only that particular line of relationship. Very much so like Y chromosome testing (let's say Y-DNA37 or Y-DNA67 at FTDNA) is only, and only looking at a patriline (father of father of etc.).

            Most likely you did not test to learn about any specific mutation, so normally you would not have any need to look at them. Genetic genealogy works by comparing results (and a computer does that for you). Did you check your mtDNA matches?

            And to broaden the picture:
            • FTDNA offers of choice of DNA tests:
              • autosomal (Family Finder)
              • FMS (mtDNA, tracing matrilineal relationships only), this the one you took
              • Y DNA STRs & SNPs (tracing patrilineal relationships only)
              • additional tests e.g. X STR markers.
            • Autosomal DNA results are limited to finding recent relationships only.
            • mtDNA and Y DNA results allow one to go much, much deeper in time, but usually one cannot even estimate the degree/level of relationship (e.g. the 3rd cousin might be indistinguishable from the 6th cousin using mtDNA or Y chromosome testing only).


            There is not a single type of a DNA test that has all the answers. However, like in any other genealogical research, all**** the potential avenues should be explored. And as in any genealogical research, funding is often a limiting factor...

            W. (Mr.)

            **** Not every DNA test type makes sense for everybody. The best known exception: Y DNA tests cannot be done by women.
            Last edited by dna; 19 April 2015, 06:52 PM.

            Comment


            • #7
              My results were never in the email, I found out only when accessing the site, where it seems every result is incomplete unless you pay to upgrade. My mother thinks it is all a scam. I was so hoping to understand this so I could put together our family history.
              Any insight is appreciated. Thank you.[/QUOTE]

              1. My daughter and I have never gotten any info in an email. We check FTdna a few times a week to see when results are expected.
              2. Mtdna just gives a general background to see where your mother's mother's line came from a few thousand years ago. My daughter did hers to see if she was Jewish. The last woman she knew of was from Prussia. The Mtdna was consistent with a woman from Northern Europe.
              I may do my Mtdna next year, just out of curiosity to see if my ancestor is European or Native American. If she is European can I find out if she is from the British Isles? I don't know if the answers will be that specific.
              3. To find 2nd cousins to 5th cousins, do Family Finder. It usually costs $99. Sometimes there is a coupon for $10 or $20 off the regular price.
              Yesterday my daughter found a 4th cousin 1 generation removed and his daughter from FF's dna matches. It only worked because she and the other daughter had excellent family trees going back to 1800. Usually we find 2nd-3rd cousins.
              I found the granddaughter of my first cousin whom I used to visit when my parents went out-of-town 80 years ago. I am 90.My dau does my typing.
              I hope you do as much as you can on your family tree, and then do the Family Finder. When you know the children of your great-great grandparents and who they each married, it's easier to make matches based on dna.

              Good luck,
              Bob

              Comment


              • #8
                So I have been emailing back and forth with the U3 project admin and she said that most of my extra mutations are fairly common; the one she was really interested in was a mutation in my Coding region (marker 9615 I think) she said that it is Unique in U3a1c as in NO ONE ELSE thus tested has it!!! (Um...WOW ) She said it will be helpful in the future, finding others who have it, as they would be much more closely related to me within U3a1c...

                Comment


                • #9
                  I am L3e2a ~ did the full seq.

                  HVR1 DIFFERENCES FROM rCRS
                  16093C
                  16223T
                  16257T
                  16290A
                  16320T
                  16519C

                  HVR2 DIFFERENCES FROM rCRS
                  73G
                  146C
                  150T
                  152C
                  195C
                  263G
                  309.1C
                  315.1C
                  522-
                  523-

                  CODING REGION DIFFERENCES FROM rCRS
                  750G
                  1438G
                  2352C
                  2706G
                  4769G
                  4823C
                  7028T
                  8701G
                  8860G
                  9196A
                  9540C
                  10398G
                  10819G
                  10873C
                  11719A
                  12705T
                  13105G
                  14212C
                  14766T
                  14869A
                  14905A
                  15301A
                  15326G


                  in my RSRV I also have!


                  Extra Mutations

                  309.1C

                  315.1C

                  G9196A

                  T16093C

                  C16257T

                  C16290a


                  Missing Mutations

                  C146T

                  C152T

                  Comment


                  • #10
                    Clarification and Thanks

                    Originally posted by dna View Post
                    It is difficult to write a response to you without knowing what you had ordered, and what you wanted to achieve.

                    From you had written so far (H5a1 - meaning you had the FMS test), your matriline (mother of your mother etc.) has European heritage. mtDNA test is examining only that particular line of relationship. Very much so like Y chromosome testing (let's say Y-DNA37 or Y-DNA67 at FTDNA) is only, and only looking at a patriline (father of father of etc.).

                    Most likely you did not test to learn about any specific mutation, so normally you would not have any need to look at them. Genetic genealogy works by comparing results (and a computer does that for you). Did you check your mtDNA matches?

                    And to broaden the picture:
                    • FTDNA offers of choice of DNA tests:
                      • autosomal (Family Finder)
                      • FMS (mtDNA, tracing matrilineal relationships only), this the one you took
                      • Y DNA STRs & SNPs (tracing patrilineal relationships only)
                      • additional tests e.g. X STR markers.
                    • Autosomal DNA results are limited to finding recent relationships only.
                    • mtDNA and Y DNA results allow one to go much, much deeper in time, but usually one cannot even estimate the degree/level of relationship (e.g. the 3rd cousin might be indistinguishable from the 6th cousin using mtDNA or Y chromosome testing only).


                    There is not a single type of a DNA test that has all the answers. However, like in any other genealogical research, all**** the potential avenues should be explored. And as in any genealogical research, funding is often a limiting factor...

                    W. (Mr.)

                    **** Not every DNA test type makes sense for everybody. The best known exception: Y DNA tests cannot be done by women.
                    Thank you to all who offered insight on my frustrations. To answer the test questions I had the full mtDNA test run on myself and the Y37 for my brother. These appeared to offer the most information for the amount I could afford at the time. I was very unsure of how to start so I consulted my niece who is a biomed student.
                    Anyway, I did look at all the links on the dashboard, but I am not sure what to do with them. I had 56 "exact matches".
                    My goal is to map our family tree, since we have many missing pieces and more questions than answers. Based on the best information that I could understand through web research, I took a shot and started with FMA.

                    Comment


                    • #11
                      EXTRA MUTATIONS

                      I have:
                      315.1C
                      T8337C
                      G8860A
                      T11299C
                      C16189T
                      C16519T

                      What is the James Lick thing do?

                      http://dna.jameslick.com/mthap/[/QUOTE]
                      Last edited by DeniseNiot; 10 March 2016, 08:04 PM. Reason: error

                      Comment

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