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Haplogroup N, HVR1 16292T, 16519C?

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  • mschris
    replied
    Hello Marcia,

    Welcome to Haplogroup N. I am also new to this and will not be able to answer all of your questions. However, my father's mt haplogroup is also N*. I am still waiting for the HV II results. My father's reported difference from CRS matches very closely to the N1a motif, but is not classified as such. I believe Cacio is correct and FTDNA does not currently test for subclades of N. However, that could change in the future.

    I believe N is a very old haplogroup. Although it is rare today, it appears to have been less rare in the neolithic and paleolithic eras. I will try to locate a few papers that provide some insight into this haplogroup.

    My father's Ysearch ID is 2VYBY. Our oldest known ancestor is Eva Bauer born in 1762 in Pennsylvania. This family is almost certainly to have immigrated from Germany or one of the germanic countries.

    Chris

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  • cacio
    replied
    The work for the genographic project is done by FTDNA, so they simply report the same result. Just to make sure, you can send them an email directly asking if
    1) you were assigned to N only on the base of the HRV1 sequence, or if they did other tests
    2) they offer other tests that may give more information.
    They usually answer nicely.

    I doubt they have any relevant test, though, if you are really N*. This is not a very common group, so I am pretty sure that they have not developed any particular test for it (unlike for other more common groups like H). One thing you could do, if you can spend $150 more, is to have ftdna test HRV2. This is another area of the mtDNA. If you get HRV2 results that are also consistent with N*, that may be useful information.

    If you have not done this before, I would upload your results on www.mitosearch.org (you can do it from your ftdna webpage). When you do so, you can have access to a large database of mtDNA data, and you can search for genetic matches. I just browsed quickly. Many people in haplogroup W share your mutations, but they usually have a couple more. Some people in N* also have your mutations, and you may have matches there. This seems to suggest that you assignment is sensible. But again, if you upload and check yourself, you can make sure that you have no matches anywhere else.

    Since your group is relatively rare, your result is very interesting. N* lineages are probably ancient, but as your result shows, they may have survived, above all in Russia, central asia and India.

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  • Marcia S.
    replied
    Cacio,
    Thanks for replying. In answer to your question, FTDNA only showed those two HVR1 numbers for me. I actually signed up for the Genographic site, then had the results transferred over. Both Genographic & FTDNA said I was in Haplogroup N. I'm wondering if I should have an additional test done to get more detail since apparently the test was only done for the 12 marker info., and if so which test would be the one to get this additional detailed DNA result? I'm beginning to think I should have taken an FTDNA test to begin with, because I see there's different marker tests that can be done.
    And thanks for trying to check further, the W haplogroup would sort of make sense. My grandmother was Ruthenian (Russian), which would place her and her parents, etc. in the Baltic location.
    Marcia S.

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  • cacio
    replied
    Are these the only two differences with the CRS? And, to determine the haplogroup, did they test only HVR1 or also other locations on the mtDNA? Sometimes people are assigned to a haplogroup only on the basis of HRV1. but often the same HRV1 can exist in different haplogroups, so further tests may be necessary.

    Haplogroup N is the name of the big group from which almost all Western Eurasian mtDNA sequences are derived. Haplogroup H is a sub-sub branch of N. However, if you were told N, but not H (or other groups), most likely it means that you belong to N but _not_ to a known studied subgroups (ie, you are not H). I quickly browsed a recent paper by Palanichamy et al. (Phylogeny of mitochondrial DNA macrohaplogroup N in India). The paper lists 16292 and 16159 as mutations defining the subgroup of haplogroup N which they call N2. One of the branches of haplogroup N2 is haplogroup W. Haplogroup W is rather rare. It is present from India to Central Asia to the Baltic area. However, I am not an expert on mtDNA, so I don't know if your HRV1 motif is found in other groups as well.

    cacio

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  • Marcia S.
    started a topic Haplogroup N, HVR1 16292T, 16519C?

    Haplogroup N, HVR1 16292T, 16519C?

    My DNA shows I'm Haplogroup N, with CRS 16292T and 16519C listed, and I'm really confused and hope someone can explain this to me. I apologize if I'm asking a stupid question, but I've seen 16519C listed with other haplogroups, in fact, it was listed on the Famous DNA site for Marie Antoinette, however she was listed with haplogroup H. I realize haplogroup N has to be an offshoot of something else, and is that where the subclave thing comes in?
    Is N an offshoot from H? I know I'm in way over my head with trying to understand DNA, and in reading over these boards you people seem to know the right answers, so a big thank you for that! So this 16519C, does this mean I share a common ancestor somewhere along the line with the French Queen, or because the haplogroups are different it means nothing? Also since I had two numbers listed 16292T and 16519C, I assume this means I have two mutations? And are these the numbers that are matched to me?
    Thanks in advance for any or all answers you can give me.
    Marcia S.
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