Free archaic admixture self analysis?

[Lipitzan]

I was curious if there was a way, using my autosomal raw data, to find out about any archaic (Neanderthal/Denisovan) admixture, via GEDMatch or any other free service? Can any information be extrapolated from Eurogene's Mesolithic-Neolithic admixture results? I'm not even sure if autosomal DNA is used to find that out.

[josh w.]

I was curious if there was a way, using my autosomal raw data, to find out about any archaic (Neanderthal/Denisovan) admixture, via GEDMatch or any other free service? Can any information be extrapolated from Eurogene's Mesolithic-Neolithic admixture results? I'm not even sure if autosomal DNA is used to find that out.

If you upload your autosomal data to Promethius you can get medical information as well as information on whether you have some of the Neanderthal lines.

[Rebekah Canada]

Hi,

Felix has some nice tools on his website.

I was curious if there was a way, using my autosomal raw data, to find out about any archaic (Neanderthal/Denisovan) admixture, via GEDMatch or any other free service? Can any information be extrapolated from Eurogene's Mesolithic-Neolithic admixture results? I'm not even sure if autosomal DNA is used to find that out.

[Lipitzan]

If you upload your autosomal data to Promethius you can get medical information as well as information on whether you have some of the Neanderthal lines.

Hi,

Felix has some nice tools on his website.

Awesome! Thanks for all your help. Going to check it out now.

Do you know the name of Felix's website?

[Lipitzan]

If you upload your autosomal data to Promethius you can get medical information as well as information on whether you have some of the Neanderthal lines.

Is Promethius a website or a project, having difficulty finding it.

[josh w.]

Is Promethius a website or a project, having difficulty finding it.

Yes, it is a website. There may be a legal issue. 23&me used to do a more comprehensive analysis but it was shut down by the Feds. The problem was that 23&me offered unjustified medical advice--maybe it was shut down for offering medical advice period. Prometheus just lists the results of scientific medical studies and does not offer medical advice. The 23&me SNP package was more inclusive than FTDNA's and covered more Neanderthal lines.

[josh w.]

Yes, it is a website. There may be a legal issue. 23&me used to do a more comprehensive analysis but it was shut down by the Feds. The problem was that 23&me offered unjustified medical advice--maybe it was shut down for offering medical advice period. Prometheus just lists the results of scientific medical studies and does not offer medical advice. The 23&me SNP package was more inclusive than FTDNA's and covered more Neanderthal lines.

My bad. The name is Promethease. Ironically, there is a testing company named Prometheus which just lost a court suit over tying to patent a gene sequence.

[Lipitzan]

My bad. The name is Promethease. Ironically, there is a testing company named Prometheus which just lost a court suit over tying to patent a gene sequence.

Ah cool. I noticed that it says there is a free version that takes 12+ hours to download and a short one that costs 5 dollars. Do you know where I can find the "free" version?

Never mind, In think they've made changes recently for that site. 5 dollars isn't so bad if it comes with health information, too.

[Ann Turner]

Yes, it is a website. There may be a legal issue. 23&me used to do a more comprehensive analysis but it was shut down by the Feds. The problem was that 23&me offered unjustified medical advice--maybe it was shut down for offering medical advice period. Prometheus just lists the results of scientific medical studies and does not offer medical advice. The 23&me SNP package was more inclusive than FTDNA's and covered more Neanderthal lines.

That's not quite accurate. 23andMe never offered medical advice per se, unless you count advice to consult your doctor about certain findings as medical advice. 23andMe differs from Promethease by basing reports on citations that meet certain standards (e.g. sample size, replication) and integrating risk factors (e.g. if you have a higher relative risk based on certain markers and a lower relative risk based on other markers). Promethease aims to be a more comprehensive repository of all articles, so it's more of a bibliographic database. It does a fantastic job of that.

The URL for Promethease is

http://www.snpedia.com/index.php/Promethease

I recommend the option to pay a nominal fee for a faster report with additional features.

You can still get a Neanderthal percentage report from 23andMe, since it's one of the ancestry features.

Another website for Neanderthal percentage is Interpretome. Unfortunately, it's down right now, but you can read about it here:

http://www.genomesunzipped.org/2011/06/interpretome-new-online-tools-for-analysing-personal-genome-data.php

[Lipitzan]

My bad. The name is Promethease. Ironically, there is a testing company named Prometheus which just lost a court suit over tying to patent a gene sequence.

That's not quite accurate. 23andMe never offered medical advice per se, unless you count advice to consult your doctor about certain findings as medical advice. 23andMe differs from Promethease by basing reports on citations that meet certain standards (e.g. sample size, replication) and integrating risk factors (e.g. if you have a higher relative risk based on certain markers and a lower relative risk based on other markers). Promethease aims to be a more comprehensive repository of all articles, so it's more of a bibliographic database. It does a fantastic job of that.

The URL for Promethease is

http://www.snpedia.com/index.php/Promethease

I recommend the option to pay a nominal fee for a faster report with additional features.

You can still get a Neanderthal percentage report from 23andMe, since it's one of the ancestry features.

Another website for Neanderthal percentage is Interpretome. Unfortunately, it's down right now, but you can read about it here:

http://www.genomesunzipped.org/2011/...enome-data.php

Thank you. I've downloaded the software, now running my gf's raw data. If it takes too long I'll just pay the 5$ for mine.

[josh w.]

That's not quite accurate. 23andMe never offered medical advice per se, unless you count advice to consult your doctor about certain findings as medical advice. 23andMe differs from Promethease by basing reports on citations that meet certain standards (e.g. sample size, replication) and integrating risk factors (e.g. if you have a higher relative risk based on certain markers and a lower relative risk based on other markers). Promethease aims to be a more comprehensive repository of all articles, so it's more of a bibliographic database. It does a fantastic job of that.

The URL for Promethease is

http://www.snpedia.com/index.php/Promethease

I recommend the option to pay a nominal fee for a faster report with additional features.

You can still get a Neanderthal percentage report from 23andMe, since it's one of the ancestry features.

Another website for Neanderthal percentage is Interpretome. Unfortunately, it's down right now, but you can read about it here:

http://www.genomesunzipped.org/2011/...enome-data.php

Thanks for the correction and clarification. What was Food and Drugs' concern?

[Ann Turner]

Thanks for the correction and clarification. What was Food and Drugs' concern?

Here's the full text of the warning letter. The FDA seemed more concerned that individuals would adjust their drug dosage or get a mastectomy without seeking further advice.

http://www.fda.gov/iceci/enforcementactions/warningletters/2013/ucm376296.htm

[Jim Barrett]

Not True

23&me used to do a more comprehensive analysis but it was shut down by the Feds.

23andMe was NOT shut down by the Feds or by anyone else. They are still selling and processing autosomal DNA just like FTDNA and Ancestry. They were forced to drop the medical side of their reports.

[josh w.]

23andMe was NOT shut down by the Feds or by anyone else. They are still selling and processing autosomal DNA just like FTDNA and Ancestry. They were forced to drop the medical side of their reports.

The FDA statement seems to point to something like 'advice', to consumers making bad choices based on the implications of 23&me statements.

Sorry I should have been more specific, I did not mean to suggest that 23&me's genealogical services were shut down. I hope that it was clear from the context that my focus was on medical information.