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Formula for calculating Neanderthal Percentage?

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  • lc0
    replied
    Originally posted by Brunetmj View Post
    In this article DNA evidence is discussed.
    http://anthro.palomar.edu/homo2/mod_homo_2.htm
    Thanks for the article. Now can someone explain in layman terms how the following two relate (quoted from the article above):

    Based on this information, Svante Paabo of the Max Planck Institute for Evolutionary Anthropology in Germany concluded that the Neandertal and modern human genomes share 99.5-99.9% of their base unit sequences.
    and
    Further analysis of the Vindija Cave Neandertal DNA by Richard Green of the University of California, Santa Cruz led him to announce in 2010 that 1-4% of the DNA in modern Europeans and Asians came from Neandertals.
    If I take the first quote it sort of suggests that 0.1-0.5% of the genome is unique for neanderthal - and thus cannot be found in humans in any similar way. So then what part of the neanderthal genome that is unique for neanderthal and is not shared by humans is nevertheless found back in 1-4% of our human genome. Doesn't rhyme to me.... or.....

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  • felix
    replied
    Originally posted by ahernandez View Post
    Thanks, Felix! Your application worked. So I got this, but what % is this?
    I am not entirely sure but I believe you have 12 mutations out of 84 !? which gives, 12*100/84 = 14.29% but what I heard and read is, only less than 4% is inherited from neanderthals to everyone outside of Africa. As I said, I am not sure. I also require someone to explain how to translate into a %.

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  • ahernandez
    replied
    Thanks, Felix! Your application worked. So I got this, but what % is this?
    Attached Files

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  • cokie
    replied
    their chromosome painting compares to their own database, I assume? so it shows me mostly as Toscani from italy, with bits of African and Mexican and Chinese and Gujarati Indian.
    From my paper research I'm mostly NW and eastern European, with a small % of African and some Native American from eastern NA most likely. The African was new to me when I tested, Dr. McDonald found that as have some other utilities, same with the Native American although family stories have said the same about the native American. I also have vague references to east Asian and SIberian in some tests which might come from the eastern European (Ukraine) in me. I also have a significant amount of middle eastern.

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  • thormalen
    replied
    Originally posted by cokie View Post
    Thanks Felix, it works beautifully. The results I got from Interpretome are somewhat.. interesting..
    Well Cokie...don't leave us in suspense!

    Leave a comment:


  • cokie
    replied
    Thanks Felix, it works beautifully. The results I got from Interpretome are somewhat.. interesting..

    Leave a comment:


  • felix
    replied
    Originally posted by cokie View Post
    Originally posted by N21163 View Post
    If you're still interested in calculating the Neanderthal component, I found a blog that tells you how to convert your ftdna raw data to [mimic] 23andme.

    *section 6. "Converting FF data to 23andMe format"
    My ftdna raw data is over 12,000 pages in MS Word and my computer freezes when I try and replace the characters as directed on the blog. Is there some other way to accomplish this?
    Try my little program (src code included).
    Attached Files

    Leave a comment:


  • cokie
    replied
    [QUOTE=N21163;364434]If you're still interested in calculating the Neanderthal component, I found a blog that tells you how to convert your ftdna raw data to [mimic] 23andme.

    *section 6. "Converting FF data to 23andMe format"

    My ftdna raw data is over 12,000 pages in MS Word and my computer freezes when I try and replace the characters as directed on the blog. Is there some other way to accomplish this?

    Leave a comment:


  • ahernandez
    replied
    Thanks. I'll try that.

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  • N21163
    replied
    Originally posted by ahernandez View Post
    Does anyone know the formula for calculating an individual's Neanderthal percentage?

    I tried to run my raw data through Interpretome and it didn't take the FTDNA file. So I ran it through Promethease and out of the 42 SNPs I got 22 (see below), that seems like more than the average of 7 to 10 SNPs for Europeans, but it doesn't give me the %. So given my result, how do I calculate the estimated percentage of Neanderthal DNA I have?
    If you're still interested in calculating the Neanderthal component, I found a blog that tells you how to convert your ftdna raw data to [mimic] 23andme.

    *section 6. "Converting FF data to 23andMe format"

    http://cryokidconfessions.blogspot.c...ftdna-raw.html

    Once you have done this you will be able to upload your new data file to Interpretome and hopefully obtain some interesting results!
    I've just uploaded mine and I have 8 out of 84 of the Neanderthal alleles....

    Not sure if this constitutes a percentage yet but will report back when I have more info:

    http://science.kqed.org/quest/2011/0...rthal-are-you/

    **Before you begin I suggest you ensure you save your original ftdna raw data in a safe location (don't want to gt things mixed up!).

    Cheers
    Last edited by N21163; 12 June 2013, 11:31 PM.

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  • Táltos
    replied
    Originally posted by Brunetmj View Post
    Here's a video

    http://m.video.pbs.org/video/2323758207/

    No the Neanderthal genes found in humans are autosomal
    Oh yes I knew that. Just wondering if they have mtDNA groups listed for them.

    Leave a comment:


  • Brunetmj
    replied
    Here's a video

    http://m.video.pbs.org/video/2323758207/

    No the Neanderthal genes found in humans are autosomal

    Leave a comment:


  • Táltos
    replied
    Originally posted by mollyblum View Post
    No offense but one article is not evidence of collective consensus, in fact, you cannot get Antropologists/Archaeologists to agree about most anything let alone something as controversial as Neanderthal modern human interbreeding.

    Personally I think it's kind of hogwash. I mean who is to say it would even be genetically possible and even if it were what is the offspring were sterile like mules?

    And no 1796- Neanderthals are portrayed as hulking brutes but they were actually about 64-67cm tall in males and about 3-4 cm less in females based upon the skeletal long bones. But if you think about it modern humans weren't 6 feet tall either. We have gotten taller with each generation due to better diet, medicine, etc. So we were actually about the same height as Neanderthals during that time period.

    But if people want to believe they are part Neanderthal, whatever.

    It reminds me of that Timothy Hutton, Lindsay Crouse, John Lone movie from about 20 years ago- Iceman. If you haven't seen it you might want to rent it. It was actually very interesting and somewhat current. Scientists in the arctic find a frozen Neanderthal (maybe it wasn't the arctic but somewhere mountainous) and figure out how to defrost him and bring him back to life. It isn't a comedy. Lol.
    Lol Mollyblum, just for clarification did you mean to say 67 inches not 67 cm. I am actually 67 inches. Thanks for your input as you have more expertise in this area as my degrees are not in anthropology or archeology.

    It seems that there is always some kind of controversy no matter what the subject matter is with this genetics business. I am curious though, do they have any mtDNA groups for Neanderthals? I need something, I don't think they are going to find my buddy the Squatch....

    Leave a comment:


  • mollyblum
    replied
    No offense but one article is not evidence of collective consensus, in fact, you cannot get Antropologists/Archaeologists to agree about most anything let alone something as controversial as Neanderthal modern human interbreeding.

    Personally I think it's kind of hogwash. I mean who is to say it would even be genetically possible and even if it were what is the offspring were sterile like mules?

    And no 1796- Neanderthals are portrayed as hulking brutes but they were actually about 64-67cm tall in males and about 3-4 cm less in females based upon the skeletal long bones. But if you think about it modern humans weren't 6 feet tall either. We have gotten taller with each generation due to better diet, medicine, etc. So we were actually about the same height as Neanderthals during that time period.

    But if people want to believe they are part Neanderthal, whatever.

    It reminds me of that Timothy Hutton, Lindsay Crouse, John Lone movie from about 20 years ago- Iceman. If you haven't seen it you might want to rent it. It was actually very interesting and somewhat current. Scientists in the arctic find a frozen Neanderthal (maybe it wasn't the arctic but somewhere mountainous) and figure out how to defrost him and bring him back to life. It isn't a comedy. Lol.



    Originally posted by Brunetmj View Post
    I think the current collective evidence points to inbreeding at some point in modern human history. Even the original non believers are coming around when confronted with the evidence. In this article DNA evidence is discussed.

    http://anthro.palomar.edu/homo2/mod_homo_2.htm

    Although I agree that current measurments should not be taken seriously the fact that it happened cannot be easily dismissed.

    Leave a comment:


  • Táltos
    replied
    Originally posted by Brunetmj View Post
    I think the current collective evidence points to inbreeding at some point in modern human history. Even the original non believers are coming around when confronted with the evidence. In this article DNA evidence is discussed.

    http://anthro.palomar.edu/homo2/mod_homo_2.htm

    Although I agree that current measurments should not be taken seriously the fact that it happened cannot be easily dismissed.
    Thanks for posting Brunetmj. Honestly I don't know much about this. They mentioned that they found different mito haplogroups for these guys. Is there an actual list of them somewhere? They would probably not match any of the known ones today correct?

    I am also surprised by how tall the average male was. I guess what I am trying to say is that somehow I always imagined Neanderthals being well over 6 feet tall.

    Leave a comment:

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