Rates of Mutations

[nc2015]

Does anyone know how long it takes for a mutation to occur, on average ? For example, if you differ from another by only 1 mutation how much of a divergence, in years, would your line be from that persons line ?

[bob_allison]

Average mutation rate per allele is usually said to be 1 in 500.

Averages are worked out by taking into account large samples and do not help much to put a particular time on a particular instance. A single mutation could have occurred one generation ago or twenty generations ago.

[nyfromca]

1 step mutation

Hi,
My dad's first cousin and my brother, our MRCA is 3 generations back, have a 1 step mutation on our 37 markers, occurring in our 3rd set of results.

Another match of mine, our MRCA is about 9 generation back, is a perfect 25 for 25 match with us. I'm sure though, if he upgraded, it might be off also.

Hope this helps some : )

Kathy

[nc2015]

Hi Kathy, Thanks for the post. It looks as though these mutations can occurr at any time. Also, I am not too familiar with the YDNA test so I am assuming when you say the third set of results you are referring to the next set of markers they would test for ? Which poses the question for me, are the tests that define your haplogroup (HVR1) more significant than the later tests ? In other words, less variable ? .. with diminishing significance the further refined you get ? .. or, are all weighted equally in terms of matching with another person. The reason I ask this is that I am off (+1-1) with 2 people, one of them I am -1 in HVR1 and +1 in HVR2, the second I am +1-1 in HVR2. Would I be more closely related to the second person who matches me exactly HVR1 or is it insignificant, and only the number of markers that are different matter (+1-1), regardless of where they are. The more I look at this stuff the more confusing it becomes ! Thanks, Laura

[Jim Denning]

Does anyone know how long it takes for a mutation to occur, on average ? For example, if you differ from another by only 1 mutation how much of a divergence, in years, would your line be from that persons line ?

one generation because the
E3b 13 24 13 10 16 18 11 12 12 13 11 30 16 9 9 11 11 26 14 20 33 14 16 16 17
in one time the 18 didnt become 18.1 or 18.5 it became 19 in the next generation not over a period of generations at least they dont put decimals on these numbers.
E3b 13 24 13 10 16 19 11 12 12 13 11 30 16 9 9 11 11 26 14 20 33 14 16 16 17

maybe some one knows if they don't report forming repeats like the 18.4 but i have never heard mention of it

[nc2015]

Thanks Jim, what I was looking for was number of generations/years. For example my mtDNA is as follows:

224 311 519 73 263 309.1 315.1 497 524.1 524.2 524.3 524.4

Another persons is:

224 311 519 73 195 263 315.1 497 524.1 524.2 524.3 524.4

As you can see I am missing their 195 and they are missing my 309.1 so what I would like to know is how many generations it took for those paths to diverge, i.e. do we have a common ancestor 400+ years ago, 1,000+ years ago, etc.

[Jim Denning]

Mtdna Is Slower I Think