LP gene

[1798]

I saw this post on another forum from a man whose origins are in India
"From my family finder data
rs182549:GG
rs4988235:CC
So I am supposed to be lactose intolerant But my daily diet includes curd , cream and curd based dishes and other milk/cream based sweets especially since both my sides of family comes from farmers . That said i dont really prefer milk but rather have it form of coffee ,tea or chocolate drinks ."

My FF LP results are;
182549 TT
4988235 AA
Maybe someone can explain these results.

[N21163]

I saw this post on another forum from a man whose origins are in India
"From my family finder data
rs182549:GG
rs4988235:CC
So I am supposed to be lactose intolerant But my daily diet includes curd , cream and curd based dishes and other milk/cream based sweets especially since both my sides of family comes from farmers . That said i dont really prefer milk but rather have it form of coffee ,tea or chocolate drinks ."

My FF LP results are;
182549 TT
4988235 AA
Maybe someone can explain these results.

According to SNPedia you are only "possibly lactose intolerant" on Rs4988235 http://snpedia.com/index.php/Rs4988235

'GG' is not listed as an option for Rs182549, but I would presume it is a similar case: http://www.snpedia.com/index.php/Rs182549

[N21163]

According to SNPedia you are only "possibly lactose intolerant" on Rs4988235 http://snpedia.com/index.php/Rs4988235

'GG' is not listed as an option for Rs182549, but I would presume it is a similar case: http://www.snpedia.com/index.php/Rs182549

I would take GG to be the same as CC

[1798]

I would take GG to be the same as CC

These LP alleles are found mostly among western Europeans!!
182549 TT
4988235 AA

[N21163]

These LP alleles are found mostly among western Europeans!!
182549 TT
4988235 AA

There will be variants though

[Gnarlodious]

Its complicated...

You may still be lactose intolerant. "Curd" as you call it is predigested by bacteria which breaks apart the lactose sugar molecule, normally called cottage cheese. Yogurt and cheese all have very low lactose, the only place lactose is really found is in liquid cow's milk. Even lactose intolerant people can drink small amounts of cow's milk, so long as they don't hit the critical amount that causes digestive failure. If you can't drink a full glass without digestive distress then you are probably lactose intolerant.

There are other factors too, besides the one lactase gene. For example, pasteurizing milk kills a lactase enzyme naturally produced by the cow (or certain breeds of cows) which assists in digesting the lactose. So "lactose intolerance" as we know it is probably the result of modern processing. It is known that there are other digestive mechanisms that enable the breakdown of lactose, although they are poorly understood. Also, lactose intolerance can be a slow development, it may not set in until the 40s for some people. One example is ashkenazi Jews who for an unknown reason continue to drink milk even though they are technically lactose intolerant. Lastly, babies naturally produce the lactase enzyme and as the child grows will continue to produce the enzyme as long as they drink milk. If they stop drinking milk they will lose the ability to produce the enzyme, though the amount of time it takes to adapt to the non-milk diet is widely variable and the mechanism not understood.

Another factor you might examine since you mentioned Indian origins is the type of milk consumed in that area. Indian cows produced a type of milk called "A2", and so your ancestors may have been adapted to digesting A2 milk. But modern dairy farms normally use the high production Holstein cows that are black-and-white. These cows produce a type of milk called A1, but more of it, like 30% more. Holsteins come from the Holstein region of southern Denmark, so Europeans and British have been drinking A1 milk for many generations. Non-Europeans may find Holstein milk gives them a bad reaction due to the different chemical properties of a certain protein in A1 milk. So the same chemistry that allows Holsteins to produce so much more milk makes it hard to digest for those not adapted to it. This is an area that is not understood and there is most certainly a genetic component to it that in the years to come will be investigated.

[1798]

You may still be lactose intolerant. "Curd" as you call it is predigested by bacteria which breaks apart the lactose sugar molecule, normally called cottage cheese. Yogurt and cheese all have very low lactose, the only place lactose is really found is in liquid cow's milk. Even lactose intolerant people can drink small amounts of cow's milk, so long as they don't hit the critical amount that causes digestive failure. If you can't drink a full glass without digestive distress then you are probably lactose intolerant.

There are other factors too, besides the one lactase gene. For example, pasteurizing milk kills a lactase enzyme naturally produced by the cow (or certain breeds of cows) which assists in digesting the lactose. So "lactose intolerance" as we know it is probably the result of modern processing. It is known that there are other digestive mechanisms that enable the breakdown of lactose, although they are poorly understood. Also, lactose intolerance can be a slow development, it may not set in until the 40s for some people. One example is ashkenazi Jews who for an unknown reason continue to drink milk even though they are technically lactose intolerant. Lastly, babies naturally produce the lactase enzyme and as the child grows will continue to produce the enzyme as long as they drink milk. If they stop drinking milk they will lose the ability to produce the enzyme, though the amount of time it takes to adapt to the non-milk diet is widely variable and the mechanism not understood.

Another factor you might examine since you mentioned Indian origins is the type of milk consumed in that area. Indian cows produced a type of milk called "A2", and so your ancestors may have been adapted to digesting A2 milk. But modern dairy farms normally use the high production Holstein cows that are black-and-white. These cows produce a type of milk called A1, but more of it, like 30% more. Holsteins come from the Holstein region of southern Denmark, so Europeans and British have been drinking A1 milk for many generations. Non-Europeans may find Holstein milk gives them a bad reaction due to the different chemical properties of a certain protein in A1 milk. So the same chemistry that allows Holsteins to produce so much more milk makes it hard to digest for those not adapted to it. This is an area that is not understood and there is most certainly a genetic component to it that in the years to come will be investigated.

The hunter gatherers were able to adopt to all these changes in their diet and that's why we are here.

[1798]

According to SNPedia you are only "possibly lactose intolerant" on Rs4988235 http://snpedia.com/index.php/Rs4988235

'GG' is not listed as an option for Rs182549, but I would presume it is a similar case: http://www.snpedia.com/index.php/Rs182549

I know that 182549GG is not listed as an option and that is why I posted it.

[Stevo]

These LP alleles are found mostly among western Europeans!!
182549 TT
4988235 AA

Those are homozygous LP (Lactase Persistent) results. I think some folks are confusing your results with the other results that you quoted.

My results are the same as yours:

rs4988235 AA (13910 TT)
rs182549 TT (22018 AA)

When read from the opposite side of the double helix, rs4988235 is called 13910, and the LP nucleotide is T. Similarly, rs182549 is called 22018 when read from the opposite side of the double helix, and the LP nucleotide is A.

When it comes to these two most common Eurasian LP variants, A and T are the LP nucleotides. G and C are the non-LP nucleotides.

In your case and mine, we were handed down an LP nucleotide by both of our parents (father and mother) at both rs4988235 and rs182549.

[1798]

Those are homozygous LP (Lactase Persistent) results. I think some folks are confusing your results with the other results that you quoted.

My results are the same as yours:

rs4988235 AA (13910 TT)
rs182549 TT (22018 AA)

When read from the opposite side of the double helix, rs4988235 is called 13910, and the LP nucleotide is T. Similarly, rs182549 is called 22018 when read from the opposite side of the double helix, and the LP nucleotide is A.

When it comes to these two most common Eurasian LP variants, A and T are the LP nucleotides. G and C are the non-LP nucleotides.

In your case and mine, we were handed down an LP nucleotide by both of our parents (father and mother) at both rs4988235 and rs182549.

"It has been suggested that the Funnelbeaker culture was the origin of the gene allowing adults of Northern European descent to digest lactose. It was claimed that in the area formerly inhabited by this culture, prevalence of the gene is virtually universal.[3] A paper published in 2007 by Burger et al. [4] indicated that the genetic variant that causes lactose persistence in most Europeans (-13,910*T) was rare or absent in early farmers from central Europe. A study published by Yuval Itan and colleagues in 2010 [5] clearly shows this. A study published in 2009, also by Itan et al.,[6] suggests that the Linear Pottery culture (also known as Linearbandkeramik or LBK), which preceded the TRB culture by some 1,500 years, was the culture in which this trait started to co-evolve with the culture of dairying.

Ancient DNA extracted from three individuals ascribed to a TRB horizon in Gökhem, Sweden, were found to possess mtDNA haplogroups H, J, and T.[7]"

Wikipedia