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Old 30th April 2017, 08:57 AM
bourgja bourgja is offline
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16294T 16304C-- which haplogroups?

Hello,

Many years ago (late 1990s) my father did an mtDNA test with Oxford Ancestry, and received the following results, deviating from CRS: 16294T 16304C.

There was some confusion with the results about whether he was assigned to haplogroup H or haplogroup T, but finally assigned him to H. (This was before they could identify subgroups like H1, H5, etc.)

They did not keep the DNA sample and unfortunately it is not possible to produce one now.

Could someone tell me which possible haplogroups could have these results?
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Old 30th April 2017, 10:06 AM
Ann Turner Ann Turner is offline
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This quite an interesting case. Haplogroup T (specifically T2b), typically also has 1696T, so the absence of that marker apparently swayed Oxford Ancestors in the direction of haplogroup H. My database of full mitochondrial sequences has 586 T2b samples. Of those, 160 don't have 16296T, so that's a substantial minority. This state of affairs was the subject of a JoGG article by David Pike.

http://www.jogg.info/pages/21/Pike.pdf

Bottom line, I'd vote for T2b.
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Old 30th April 2017, 02:51 PM
bourgja bourgja is offline
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Quote:
Originally Posted by Ann Turner View Post
This quite an interesting case. Haplogroup T (specifically T2b), typically also has 1696T, so the absence of that marker apparently swayed Oxford Ancestors in the direction of haplogroup H. My database of full mitochondrial sequences has 586 T2b samples. Of those, 160 don't have 16296T, so that's a substantial minority. This state of affairs was the subject of a JoGG article by David Pike.

http://www.jogg.info/pages/21/Pike.pdf

Bottom line, I'd vote for T2b.
Okay, so I checked an email from Oxford Ancestry (from 2003) that explained that the absence of a mutation at 16126 justified their placement in H rather than T.

They said that on very rare occasions the mutation reverts back to the standard, so it is not 100% certain.
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Old 30th April 2017, 03:02 PM
Ann Turner Ann Turner is offline
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That's a valid point. Really, the only way to tell for sure would be to locate a relative who would have the same mtDNA and do a full mitochondrial sequence.
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