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Old 7th January 2017, 01:32 AM
PNGarrison PNGarrison is offline
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Reconstructing genetic history of Siberian and Northeastern European populations

Reconstructing genetic history of Siberian and Northeastern European populations
http://www.genome.org/cgi/doi/10.1101/gr.202945.115.
open access after 6 months
Emily H.M. Wong1, Andrey Khrunin2, Larissa Nichols2, Dmitry Pushkarev3, Denis Khokhrin2, Dmitry Verbenko2, Oleg Evgrafov4, James Knowles4, John Novembre5, Svetlana Limborska2 and Anton Valouev1
+ Author Affiliations

1Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90089, USA;
2Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russian Federation;
3Illumina, Incorporated, Advanced Research Group, San Diego, California 92122, USA;
4Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, California 90033, USA;
5Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
Corresponding authors: limbor@img.ras.ru, valouev@usc.edu
Abstract

Siberia and Northwestern Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups, yet genetic variation and histories of peoples from this region are largely uncharacterized. We present deep whole-genome sequencing data (∼38×) from 28 individuals belonging to 14 distinct indigenous populations from that region. We combined these data sets with additional 32 modern-day and 46 ancient human genomes to reconstruct genetic histories of several indigenous Northern Eurasian populations. We found that Siberian and East Asian populations shared 38% of their ancestry with a 45,000-yr-old Ust’-Ishim individual who was previously believed to have no modern-day descendants. Western Siberians trace 57% of their ancestry to ancient North Eurasians, represented by the 24,000-yr-old Siberian Mal'ta boy MA-1. Eastern Siberian populations formed a distinct sublineage that separated from other East Asian populations ∼10,000 yr ago. In addition, we uncovered admixtures between Siberians and Eastern European hunter-gatherers from Samara, Karelia, Hungary, and Sweden (from 8000–6600 yr ago); Yamnaya people (5300–4700 yr ago); and modern-day Northeastern Europeans. Our results provide new insights into genetic histories of Siberian and Northeastern European populations and evidence of ancient gene flow from Siberia into Europe.
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Old 8th January 2017, 04:43 PM
Petra Petra is offline
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Thank you for the interesting link.
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