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  #1  
Old 8th November 2017, 12:37 AM
Guracha Guracha is offline
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Join Date: Nov 2017
Posts: 1
Uploading raw data from 23andMe V5

Hi,

When are you going to be able to process uploading of raw data format 23andMe© V5? Many thanks
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  #2  
Old 8th November 2017, 01:36 AM
prairielad prairielad is offline
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Join Date: Feb 2011
Location: Canada
Posts: 2,021
I don't see it happening at all. 23andmeV5 chip only shares around 160,000 SNPs out of the 700,000 FTDNA tests.
There is too big of a difference between them to accurately compare
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  #3  
Old 8th November 2017, 05:26 AM
Jim Barrett Jim Barrett is offline
R-BY39877
 
Join Date: Apr 2003
Location: Timpson, TX
Posts: 2,258
Even GEDmatch set up a new data base for 23andMe V5.
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  #4  
Old 11th November 2017, 10:52 PM
wombat wombat is offline
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Join Date: Apr 2015
Posts: 275
I fear that even at 23 they are getting a touch wonky matching V5 testers to their V4 and V3 testers.
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  #5  
Old 11th November 2017, 11:34 PM
prairielad prairielad is offline
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Join Date: Feb 2011
Location: Canada
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Quote:
Originally Posted by wombat View Post
I fear that even at 23 they are getting a touch wonky matching V5 testers to their V4 and V3 testers.
Understandable if they are just relying on comparing the shared SNPs between the Versions
V5 does not even share many SNPs with their previous versions

https://isogg.org/wiki/Autosomal_SNP_comparison_chart
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  #6  
Old 12th November 2017, 01:39 PM
teyoung teyoung is offline
R-A287, J2a1a1b
 
Join Date: May 2007
Posts: 173
Quote:
Originally Posted by wombat View Post
I fear that even at 23 they are getting a touch wonky matching V5 testers to their V4 and V3 testers.
I am a v2 and saw a chart recently the I have less than 100,000 SNPs in common with v5. I still get matches, so they must be imputing.
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  #7  
Old 12th November 2017, 01:58 PM
KATM KATM is offline
mtDNA: K1a3 | Y-DNA: R-L1308*
 
Join Date: Nov 2012
Location: Mid-Atlantic coast, U.S.A.
Posts: 1,100
Quote:
Originally Posted by teyoung View Post
I am a v2 and saw a chart recently the I have less than 100,000 SNPs in common with v5. I still get matches, so they must be imputing.
Ah, imputing. Roberta Estes' most recent post on it was "Imputation Analysis Utilizing Promethease," but has links in the first paragraph to her other two posts on imputation. Here are some relevant comments from the above post (my bolding):

Quote:
As related to genetic genealogy, I don’t think imputation and genetic genealogy are good bedfellows. DNA.Land’s matching was even worse when it was initially introduced, which is one reason I’ve waited so long to upload and write about the service.

Unfortunately, with Illumina obsoleting the OmniExpress chip, we’re not going to have a choice, sooner than later. All vendors who utilized the OmniExpress chip are being forced off, either onto the GSA chip or to an Exome or full sequence chip. The cost of sequencing for anything other than the GSA chip is simply more than the genetic genealogy market will stand, not to mention even larger compatibility issues. My Genos Exome test cost $499 just a few months ago and still sells for that price today.

The good news is that utilizing imputation, we will still receive matches, just less accurate matches when comparing the new chip to older versions, and when using imputation.

New testers will never know the difference. Testers not paying close attention won’t notice or won’t realize either. That leaves the rest of us “old timers” who want increased accuracy and specification, not less, flapping in the wind along with the vendors who don’t sell our test results into the medical arena and have no reason to move to the new GSA platform other than Illumina obsoleting the OmniExpress chip.

Like I said, thanks Illumina.
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  #8  
Old 28th May 2018, 01:22 AM
oleg.meier oleg.meier is offline
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Join Date: May 2018
Posts: 2
I've just converted V5 to V4 with

https://github.com/2sh/vcf-to-23andme

First converted to genome.db than back to 23andme. upload successfull
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  #9  
Old 28th May 2018, 07:51 PM
prairielad prairielad is offline
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Join Date: Feb 2011
Location: Canada
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Quote:
Originally Posted by oleg.meier View Post
I've just converted V5 to V4 with

https://github.com/2sh/vcf-to-23andme

First converted to genome.db than back to 23andme. upload successfull
Believe above imputes values, personally I think it would be just be better to spend the $79 for Family Finder and receive the actual tested values (approximately 700000 tested and verified SNPs) vs imputed ones (up to 540000 imputed SNPS)


https://dna-explained.com/2017/10/04...ng-comparison/

Last edited by prairielad; 28th May 2018 at 07:55 PM.
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  #10  
Old 3rd July 2018, 02:02 PM
mathewcarnage mathewcarnage is offline
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Join Date: Jul 2018
Posts: 1
Raw data

Raw data from the 23andme v5 chip is unsupported by many tools. Some of them that produce reports from this version of the chip are, Promethease and Xcode Life

Last edited by Darren; 5th July 2018 at 11:50 PM. Reason: links removed
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